The Social Behavioral Phenotype in Boys and Girls with an Extra X Chromosome (Klinefelter Syndrome and Trisomy X): A Comparison with Autism Spectrum Disorder

被引：55

作者：

van Rijn, Sophie ^{[1
,2
]}

Stockmann, Lex ^{[1
,3
]}

Borghgraef, Martine ^{[4
]}

Bruining, Hilgo ^{[5
]}

van Ravenswaaij-Arts, Conny ^{[6
]}

Govaerts, Lutgarde ^{[7
]}

Hansson, Kerstin ^{[8
]}

Swaab, Hanna ^{[1
,2
]}

机构：

[1] Leiden Univ, NL-2333 AK Leiden, Netherlands

[2] Leiden Inst Brain & Cognit, NL-2300 RC Leiden, Netherlands

[3] Autism Ctr Rivierduinen, NL-2333 ZZ Leiden, Netherlands

[4] Univ Hosp Leuven, Ctr Human Genet, B-3000 Louvain, Belgium

[5] Univ Utrecht, Univ Med Ctr Utrecht, Dept Psychiat, NL-3584 CX Utrecht, Netherlands

[6] Univ Groningen, Univ Med Ctr Groningen, Dept Genet, NL-9700 RB Groningen, Netherlands

[7] Erasmus MC, Dept Clin Genet, NL-3015 GE Rotterdam, Netherlands

[8] Leiden Univ, Med Ctr, Dept Clin Genet, LDGA, NL-2300 RC Leiden, Netherlands

来源：

JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS | 2014年 / 44卷 / 02期

关键词：

Klinefelter; Trisomy X; Autism; Social functioning; X chromosome; Sex chromosomal aneuploidies; CHILDREN; ABNORMALITIES; TRAITS; ADULTS; XYY; MEN; XXY;

D O I：

10.1007/s10803-013-1860-5

中图分类号：

B844 [发展心理学（人类心理学）];

学科分类号：

040202 ;

摘要：

The present study aimed to gain more insight in the social behavioral phenotype, and related autistic symptomatology, of children with an extra X chromosome in comparison to children with ASD. Participants included 60 children with an extra X chromosome (34 boys with Klinefelter syndrome and 26 girls with Trisomy X), 58 children with ASD and 106 controls, aged 9 to 18 years. We used the Autism Diagnostic Interview, Social Responsiveness Scale, Social Anxiety Scale and Social Skills Rating System. In the extra X group, levels of social dysfunction and autism symptoms were increased, being in between controls and ASD. In contrast to the ASD group, the extra X group showed increased social anxiety. The effects were similar for boys and girls with an extra X chromosome.

引用

页码：310 / 320

页数：11

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