How do peptide synthetases generate structural diversity?

被引：208
|
作者：
Konz, D [1 ]
Marahiel, MA [1 ]
机构：
[1] Univ Marburg, Fachbereich Chem Biochem, D-35032 Marburg, Germany
来源：
CHEMISTRY & BIOLOGY | 1999年 / 6卷 / 02期
关键词：
D O I：
10.1016/S1074-5521(99)80002-7
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Many low-molecular-weight peptides of microbial origin are synthesized nonribosomally on large multifunctional proteins, termed peptide synthetases, These enzymes contain repeated building blocks in which several defined domains catalyze specific reactions of peptide synthesis. The order of these domains within the enzyme determines the sequence and structure of the peptide product.
引用
收藏
页码：R39 / R48
页数：10
相关论文
共 50 条
  • [41] Design and application of multimodular peptide synthetases
    Mootz, HD
    Marahiel, MR
    CURRENT OPINION IN BIOTECHNOLOGY, 1999, 10 (04) : 341 - 348
  • [42] THE ORGANIZATION OF MULTIFUNCTIONAL PEPTIDE AND DEPSIPEPTIDE SYNTHETASES
    VONDOHREN, H
    BIOCHEMICAL SOCIETY TRANSACTIONS, 1993, 21 (01) : 214 - 217
  • [43] Peptide synthetases, multifunctional modular enzymes
    Rebuffat, S
    Péduzzi, J
    Leclerc, G
    ACTUALITE CHIMIQUE, 2002, (8-9): : 9 - 12
  • [44] Nonribosomal peptide synthetases: structures and dynamics
    Strieker, Matthias
    Tanovic, Alan
    Marahiel, Mohamed A.
    CURRENT OPINION IN STRUCTURAL BIOLOGY, 2010, 20 (02) : 234 - 240
  • [45] Dissecting and Exploiting Nonribosomal Peptide Synthetases
    Qing-Tao SHEN
    Acta Biochimica et Biophysica Sinica, 2004, (04) : 243 - 249
  • [46] Tailor-Made Peptide Synthetases
    Kries, Hajo
    Hilvert, Donald
    CHEMISTRY & BIOLOGY, 2011, 18 (10): : 1206 - 1207
  • [47] Flexing and Stretching in Nonribosomal Peptide Synthetases
    Pfennig, Sabrina
    Stubbs, Milton T.
    CHEMISTRY & BIOLOGY, 2012, 19 (02): : 167 - 169
  • [48] How and Why Do Neurons Generate Complex Rhythms with Various Frequencies?
    Chay, Teresa Ree
    Lee, Young Seek
    DISCRETE DYNAMICS IN NATURE AND SOCIETY, 1998, 2 (04)
  • [49] How do You Map a Von Karman Vortex Street and How do You Use One to Generate Electricity?
    Divett, Tim
    JUNCTURES-THE JOURNAL FOR THEMATIC DIALOGUE, 2018, (19): : 66 - 68
  • [50] How do invertebrates generate a highly specific innate immune response?
    Schulenburg, Hinrich
    Boehnisch, Claudia
    Michiels, Nico K.
    MOLECULAR IMMUNOLOGY, 2007, 44 (13) : 3338 - 3344
12345