How do peptide synthetases generate structural diversity?

被引：208

作者：

Konz, D ^{[1
]}

Marahiel, MA ^{[1
]}

机构：

[1] Univ Marburg, Fachbereich Chem Biochem, D-35032 Marburg, Germany

来源：

CHEMISTRY & BIOLOGY | 1999年 / 6卷 / 02期

关键词：

D O I：

10.1016/S1074-5521(99)80002-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Many low-molecular-weight peptides of microbial origin are synthesized nonribosomally on large multifunctional proteins, termed peptide synthetases, These enzymes contain repeated building blocks in which several defined domains catalyze specific reactions of peptide synthesis. The order of these domains within the enzyme determines the sequence and structure of the peptide product.

引用

页码：R39 / R48

页数：10

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