Synthesis of tetralene- and chromene-based 4EGI-1 mimetics as inhibitors of eIF4E/eIF4G interaction

被引:0
|
作者
Mahalingam, Poornachandran
Wang, Yibo
Chen, Limo
Zhang, Nancy
Levy, Jay J.
Papadopoulos, Evangelous
Aktas, Bertal H.
Wagner, Gerhard
Halperin, Jose A.
Chorev, Michael
机构
[1] Harvard Univ, Sch Med, Lab Translat Res, Cambridge, MA 02138 USA
[2] Indiana Univ, Dept Chem, Bloomington, IN USA
[3] Harvard Univ, Sch Med, Dept Biol Chem & Mol Pharmacol, Boston, MA 02115 USA
[4] Brigham & Womens Hosp, Dept Med, Boston, MA 02115 USA
来源
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY | 2010年 / 240卷
关键词
D O I
暂无
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
479-MEDI
引用
收藏
页数:1
相关论文
共 50 条
  • [21] Binding of eukaryotic translation initiation factor 4E (eIF4E) to eIF4G represses translation of uncapped mRNA
    Tarun, SZ
    Sachs, AB
    MOLECULAR AND CELLULAR BIOLOGY, 1997, 17 (12) : 6876 - 6886
  • [22] Structural motifs in eIF4G and 4E-BPs modulate their binding to eIF4E to regulate translation initiation in yeast
    Gruener, Stefan
    Weber, Ramona
    Peter, Daniel
    Chung, Min-Yi
    Igreja, Catia
    Valkov, Eugene
    Izaurralde, Elisa
    NUCLEIC ACIDS RESEARCH, 2018, 46 (13) : 6893 - 6908
  • [23] Ribosome loading onto the mRNA cap is driven by conformational coupling between eIF4G and eIF4E
    Gross, JD
    Moerke, NJ
    von der Haar, T
    Lugovskoy, AA
    Sachs, AB
    McCarthy, JEG
    Wagner, G
    CELL, 2003, 115 (06) : 739 - 750
  • [24] Accumulation of polyadenylated mRNA, Pab1, eIF4E, and eIF4G with P-bodies in Saccharomyces cerevisiae
    Brengues, Muriel
    Parker, Roy
    MOLECULAR BIOLOGY OF THE CELL, 2007, 18 (07) : 2592 - 2602
  • [25] Meal feeding enhances formation of eIF4F in skeletal muscle: role of increased eIF4E availability and eIF4G phosphorylation
    Vary, TC
    Lynch, CJ
    AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2006, 290 (04): : E631 - E642
  • [26] Interaction of 2A proteinase of human rhinovirus genetic group A with eIF4E is required for eIF4G cleavage during infection
    Aumayr, Martina
    Schrempf, Anna
    Uezuelmez, Oeykue
    Olek, Karin M.
    Skern, Tim
    VIROLOGY, 2017, 511 : 123 - 134
  • [27] Loss-of-Function Analysis Reveals Distinct Requirements of the Translation Initiation Factors eIF4E, eIF4E-3, eIF4G and eIF4G2 in Drosophila Spermatogenesis
    Ghosh, Sanjay
    Lasko, Paul
    PLOS ONE, 2015, 10 (04):
  • [28] The eIF4E/eIF4G Interaction Inhibitor 4EGI-1 Augments TRAIL-Mediated Apoptosis through c-FLIP Down-regulation and DR5 Induction Independent of Inhibition of Cap-Dependent Protein Translation
    Fan, Songqing
    Li, Yikun
    Yue, Ping
    Khuri, Fadlo R.
    Sun, Shi-Yong
    NEOPLASIA, 2010, 12 (04): : 346 - U72
  • [29] Molecular dynamics simulations revealed topological frustration in the binding-wrapping process of eIF4G with eIF4E
    Gao, Meng
    Huang, Yongqi
    PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 2024, 26 (03) : 2073 - 2081
  • [30] Crystal structures of fungal eIF4G and 4E-BPs bound to eIF4E provide insight into the regulation of translation initiation
    Gruener, S.
    Chung, M.
    Valkov, E.
    Igreja, C.
    Izaurralde, E.
    FEBS JOURNAL, 2017, 284 : 41 - 41