Functional clinical outcomes in multiple sclerosis: Current status and future prospects

被引：25

作者：

Karabudak, Rana ^{[1
]}

Dahdaleh, Maurice ^{[2
]}

Aljumah, Mohammed ^{[3
,16
]}

Alroughani, Raed ^{[4
,17
]}

Alsharoqi, I. Ahmed ^{[5
]}

AlTahan, Abdulrahman M. ^{[6
,7
]}

Bohlega, Saeed A. ^{[8
]}

Daif, Abdulkader ^{[6
,7
]}

Deleu, Dirk ^{[9
]}

Amous, Amer ^{[10
]}

Inshasi, Jihad S. ^{[11
,12
]}

Rieckmann, Peter ^{[13
]}

Sahraian, Mohammed A. ^{[14
]}

Yamout, Bassem I. ^{[15
]}

机构：

[1] Hacettepe Univ Hosp, Dept Neurol, Neuroimmunol Unit, Ankara, Turkey

[2] Arab Med Ctr & Khalidi Hosp, Neurol Sect, Dept Internal Med, Amman, Jordan

[3] King Saud Ben Abdulaziz Univ Hlth Sci, King Abdullah Int Med Res Ctr, Riyadh, Saudi Arabia

[4] Amiri Hosp, Div Neurol, Kuwait, Kuwait

[5] Salmaniya Med Complex, Dept Clin Neurosci, Manama, Bahrain

[6] King Saud Univ, King Khalid Univ Hosp, Neurol Sect, Riyadh 11451, Saudi Arabia

[7] Dallah Hosp, Riyadh, Saudi Arabia

[8] King Faisal Specialist Hosp & Res Ctr, Dept Neurosci, Riyadh 11211, Saudi Arabia

[9] Hamad Med Corp, Dept Med Neurol, Doha, Qatar

[10] Merck Serono Intercontinental Reg, Dubai, U Arab Emirates

[11] Rashid Hosp, Dept Neurol, Oud Metha, U Arab Emirates

[12] Dubai Med Coll, Dubai Hlth Author, Dubai, U Arab Emirates

[13] Neurol Clin, Bamberg, Germany

[14] Univ Tehran Med Sci, Inst Neurosci, MS Res Ctr, Tehran, Iran

[15] Amer Univ, Beirut Med Ctr, Multiple Sclerosis Ctr, Beirut, Lebanon

[16] Prince Mohammed Bin Abdul Aziz Hosp, Minist Hlth, Riyadh, Saudi Arabia

[17] Dasman Diabet Inst, Div Neurol, Kuwait, Kuwait

来源：

MULTIPLE SCLEROSIS AND RELATED DISORDERS | 2015年 / 4卷 / 03期

关键词：

Multiple sclerosis; Clinical outcome measures; Disease-modifying therapies; Clinical trials; QUALITY-OF-LIFE; DISABILITY STATUS SCALE; TIMED 25-FOOT WALK; CONTRAST VISUAL-ACUITY; DISEASE-ACTIVITY; COGNITIVE IMPAIRMENT; LAYER THICKNESS; COMPOSITE; MS; PERFORMANCE;

D O I：

10.1016/j.msard.2015.03.004

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

For decades, the Expanded Disability Status Scale (EDSS) has been the principal measure of disability in clinical trials in patients with multiple sclerosis (MS) and in clinical practice. However, this test is dominated by effects on ambulation. Composite endpoints may provide a more sensitive measure of MS-related disability through the measurement of additional neurological functions. The MS Functional Composite (MSFC) includes a walking test (25-ft walk) plus tests of upper extremity dexterity (9-hole peg test) and cognitive function (Paced Auditory serial Addition test [PASAT]). Replacing PASAT with the Symbol Digit Modality test, a more sensitive test preferred by patients, may improve the clinical utility of the MSFC. In addition, disease-specific measures of QoL may be used alongside the MSFC (which does not include measurement of QoL). Clinical data suggest that disease-modifying therapies may delay or prevent relapse, and better composite measures will be valuable in the assessment of disease activity-free status in people with MS. (C) 2015 Elsevier B.V. All rights reserved.

引用

页码：192 / 201

页数：10

共 50 条

[41] Pneumoconiosis: current status and future prospects
Qi, Xian-Mei
Luo, Ya
Song, Mei-Yue
Liu, Ying
Shu, Ting
Pang, Jun-Ling
Wang, Jing
Wang, Chen
CHINESE MEDICAL JOURNAL, 2021, 134 (08) : 898 - 907
[42] RADIODIAGNOSIS - CURRENT STATUS AND PROSPECTS FOR THE FUTURE
ROZENSHTRAUKH, LS
KLINICHESKAYA MEDITSINA, 1987, 65 (11): : 78 - 84
[43] Gastroenterology, current status and prospects for the future
Ivashkin, VT
Komarov, FI
TERAPEVTICHESKII ARKHIV, 2002, 74 (02) : 5 - 8
[44] INTERSPUTNIK: Current status and future prospects
Bakmann, N
Borovkov, V
Rodriguez, O
2ND INTERNATIONAL CONFERENCE ON SATELLITE COMMUNICATIONS - PROCEEDINGS OF ICSC '96, VOLS 1-4, 1996, : 21 - 23
[45] Pneumoconiosis: current status and future prospects
Qi Xian-Mei
Luo Ya
Song Mei-Yue
Liu Ying
Shu Ting
Pang Jun-Ling
Wang Jing
Wang Chen
中华医学杂志英文版, 2021, 134 (08) : 898 - 907
[46] Clinical Trials with Oncolytic Measles Virus: Current Status and Future Prospects
Msaouel, Pavlos
Opyrchal, Mateusz
Dispenzieri, Angela
Peng, Kah Whye
Federspiel, Mark J.
Russell, Stephen J.
Galanis, Evanthia
CURRENT CANCER DRUG TARGETS, 2018, 18 (02) : 177 - 187
[47] PET/MRI for Gastrointestinal Imaging: Current Clinical Status and Future Prospects
Fraum, Tyler J.
Ludwig, Daniel R.
Hope, Thomas A.
Fowler, Kathryn J.
GASTROENTEROLOGY CLINICS OF NORTH AMERICA, 2018, 47 (03) : 691 - +
[48] Clinical electrophysiology of vision-commentary on current status and future prospects
Hamilton, Ruth
EYE, 2021, 35 (09) : 2341 - 2343
[49] Current status and future directions of disease modifying therapy in multiple sclerosis
Segal, Benjamin M.
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2013, 245
[50] FUNCTIONAL-EVALUATION OF CLINICAL STATUS IN MULTIPLE-SCLEROSIS
PANZER, VP
SMITH, ME
MARTIN, R
MALONI, H
NOVEAU, I
FRANK, J
MCFARLIN, DE
MCFARLAND, HF
ANNALS OF NEUROLOGY, 1991, 30 (02) : 271 - 271

← 1 2 3 4 5 →