Magnetic targeting core/shell Fe3O4/Au nanoparticles for magnetic resonance/photoacoustic dual-modal imaging

被引：31
|
作者：
Kang, Ning [1 ]
Xu, Dan [1 ]
Han, Yu [1 ]
Lv, Xiaolin [1 ]
Chen, Zhiwei [2 ]
Zhou, Tiantian [2 ]
Ren, Lei [1 ,3 ]
Zhou, Xi [1 ,3 ]
机构：
[1] Xiamen Univ, Coll Mat, Dept Biomat, State Key Lab Phys Chem Solid Surfaces, Xiamen 361005, Peoples R China
[2] Xiamen Univ, Dept Elect Sci, Fujian Prov Key Lab Plasma & Magnet Resonance Res, Xiamen 361005, Peoples R China
[3] Fujian Collaborat Innovat Ctr Exploitat & Utiliza, Xiamen 361005, Peoples R China
来源：
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS | 2019年 / 98卷
基金：
美国国家科学基金会;
关键词：
Fe3O4/Au nanoparticles; Dual-modal imaging; MR imaging; PA imaging; Magnetic targeting; MULTIMODALITY; DESIGN; MRI;
D O I：
10.1016/j.msec.2019.01.013
中图分类号：
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号：
0805 ; 080501 ; 080502 ;
摘要：
This study reports magnetic targeting guided magnetic (MR)/photoacoustic (PA) dual-modal imaging by core/shell Fe3O4/Au nanoparticles. In this work, MR imaging provides time-dependent tumor location, and PA imaging reveals high resolution vasculatures inside the tumor. It is noted that the synthesized Fe3O4/Au nanoparticles exhibited higher r(2) value up to 329 mM(-1) s(-1) than previously reported T-2 contrast agents. Furthermore, the Fe3O4/Au NPs are applied as a promising candidate for in vivo MR/PA imaging of tumors by intravenously injection into LNCaP tumor-beared mice. The MR/PA imaging results show a significantly enhanced MR/PA images in the tumor site. The prepared core/shell Fe3O4/Au nanoparticles will be widely applicable in multi-modal imaging.
引用
收藏
页码：545 / 549
页数：5
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