Alternatively spliced isoforms of the Na+/Ca2+ exchanger in the guinea pig cochlea

被引：13
|
作者：
Oshima, T
Ikeda, K
Furukawa, M
Takasaka, T
机构：
[1] Department of Otolaryngology, Tohoku Univ. School of Medicine 1-1, Sendai, 980-77, Seiryo-machi, Aoba-ku
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1997年 / 233卷 / 03期
关键词：
D O I：
10.1006/bbrc.1997.6533
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The cochlea has been suggested to express some Na+/Ca2+ exchangers (NCX), since efficient acoustic transduction requires cytosolic calcium homeostasis. The present study revealed that several spliced isoforms of NCX are expressed in the guinea pig cochlea. Moreover, to determine their localization in the cochlea, microdissected RT-PCR was performed. The guinea pig cochlea was microdissected into three parts (lateral wall, the organ of Corti and modiolus). The cochlear lateral wall and the organ of Corti expressed only a single isoform of NCX1. On the other hand, five isoforms of NCX1 and four isoforms of NCX3 were detected in the cochlear modiolus. The alternative splicing may provide diverse functions for NCX in the cochlea. (C) 1997 Academic Press.
引用
收藏
页码：737 / 741
页数：5
相关论文
共 50 条
  • [31] ROS are required for rapid reactivation of Na+/Ca2+ exchanger in hypoxic reoxygenated guinea pig ventricular myocytes
    Eigel, BN
    Gursahani, H
    Hadley, RW
    AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2004, 286 (03): : H955 - H963
  • [32] Dual signaling pathways of Na+/Ca2+ exchanger activation by hydrogen peroxide in guinea pig ventricular myocytes
    Hinata, M
    Matsuoka, I
    Iwamoto, T
    Kimura, J
    BIOPHYSICAL JOURNAL, 2004, 86 (01) : 227A - 227A
  • [33] Na+/Ca2+ exchanger, learning, and memory
    不详
    NEUROSCIENTIST, 2003, 9 (06): : 427 - 427
  • [34] Relative abundance of α2 Na+ pump isoforms influences Na+/Ca2+ exchanger currents in mouse ventricular myocytes
    Su, Z
    Moseley, A
    Li, FH
    Lingrel, JB
    Barry, WH
    BIOPHYSICAL JOURNAL, 2003, 84 (02) : 151A - 151A
  • [35] Topics on the Na+/Ca2+ exchanger:: Preface
    Kimura, Junko
    JOURNAL OF PHARMACOLOGICAL SCIENCES, 2006, 102 (01) : 6 - 6
  • [36] Transcriptional control of the Na+/Ca2+ exchanger
    Gabellini, N
    Zatti, A
    Carafoli, E
    CONTROL AND DISEASES OF SODIUM DEPENDENT TRANSPORT PROTEINS AND ION CHANNELS, 2000, 1208 : 69 - 72
  • [37] Shedding light on the Na+/Ca2+ exchanger
    Ottolia, Michela
    John, Scott
    Xie, Yi
    Ren, Xiaoyan
    Philipson, Kenneth D.
    SODIUM-CALCIUM EXCHANGE AND THE PLASMA MEMBRANE CA2+-ATPASE IN CELL FUNCTION: FIFTH INTERNATIONAL CONFERENCE, 2007, 1099 : 78 - 85
  • [38] IS THERE A NA+/CA2+ EXCHANGER IN MACROPHAGES AND IN LYMPHOCYTES
    DONNADIEU, E
    TRAUTMANN, A
    PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 1993, 424 (5-6): : 448 - 455
  • [39] Na+/Ca2+ exchanger in porcine oocytes
    Macháty, Z
    Ramsoondar, JJ
    Bonk, AJ
    Prather, RS
    Bondioli, KR
    BIOLOGY OF REPRODUCTION, 2002, 67 (04) : 1133 - 1139
  • [40] Structural basis for Ca2+ regulation in the Na+/Ca2+ exchanger
    Hilge, Mark
    Aelen, Jan
    Perrakis, Anastassis
    Vuister, Geerten W.
    SODIUM-CALCIUM EXCHANGE AND THE PLASMA MEMBRANE CA2+-ATPASE IN CELL FUNCTION: FIFTH INTERNATIONAL CONFERENCE, 2007, 1099 : 7 - 15
12345