Alternatively spliced isoforms of the Na+/Ca2+ exchanger in the guinea pig cochlea

被引：13
|
作者：
Oshima, T
Ikeda, K
Furukawa, M
Takasaka, T
机构：
[1] Department of Otolaryngology, Tohoku Univ. School of Medicine 1-1, Sendai, 980-77, Seiryo-machi, Aoba-ku
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1997年 / 233卷 / 03期
关键词：
D O I：
10.1006/bbrc.1997.6533
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The cochlea has been suggested to express some Na+/Ca2+ exchangers (NCX), since efficient acoustic transduction requires cytosolic calcium homeostasis. The present study revealed that several spliced isoforms of NCX are expressed in the guinea pig cochlea. Moreover, to determine their localization in the cochlea, microdissected RT-PCR was performed. The guinea pig cochlea was microdissected into three parts (lateral wall, the organ of Corti and modiolus). The cochlear lateral wall and the organ of Corti expressed only a single isoform of NCX1. On the other hand, five isoforms of NCX1 and four isoforms of NCX3 were detected in the cochlear modiolus. The alternative splicing may provide diverse functions for NCX in the cochlea. (C) 1997 Academic Press.
引用
收藏
页码：737 / 741
页数：5
相关论文
共 50 条
  • [1] Functional regulation of alternatively spliced Na+/Ca2+ exchanger (NCX1) isoforms
    Schulze, DH
    Polumuri, SK
    Gille, T
    Ruknudin, A
    CELLULAR AND MOLECULAR PHYSIOLOGY OF SODIUM-CALCIUM EXCHANGE, 2002, 976 : 187 - 196
  • [2] Properties of Ca2+-binding domains of the alternatively spliced isoforms of the Na+/Ca2+ exchanger NCX1
    Torry, Lisa
    Lytton, J.
    BIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE, 2011, 89 (02): : 270 - 270
  • [3] Identification of alternatively spliced Na+-Ca2+ exchanger isoforms expressed in the heart
    Kim, I
    Koh, GY
    Lee, CO
    COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY, 1998, 119 (01): : 157 - 161
  • [4] Regulation of mesangial cell Na+/Ca2+ exchanger isoforms
    Williams, I
    Williams, C
    Siroky, B
    Bates, E
    Kovacs, G
    Peti-Peterdi, J
    Unlap, MT
    Bell, PD
    JOURNAL OF CELLULAR PHYSIOLOGY, 2004, 199 (02) : 181 - 193
  • [5] Na+/Ca2+ exchanger isoforms of rat odontoblasts and osteoblasts
    Lundquist, P
    Lundgren, T
    Gritli-Linde, A
    Linde, A
    CALCIFIED TISSUE INTERNATIONAL, 2000, 67 (01) : 60 - 67
  • [6] Na+/Ca2+ Exchanger Isoforms of Rat Odontoblasts and Osteoblasts
    P. Lundquist
    T. Lundgren
    A. Gritli-Linde
    A. Linde
    Calcified Tissue International, 2000, 67 : 60 - 67
  • [7] MUTUALLY EXCLUSIVE AND CASSETTE EXONS UNDERLIE ALTERNATIVELY SPLICED ISOFORMS OF THE NA/CA EXCHANGER
    KOFUJI, P
    LEDERER, WJ
    SCHULZE, DH
    BIOPHYSICAL JOURNAL, 1994, 66 (02) : A330 - A330
  • [8] MUTUALLY EXCLUSIVE AND CASSETTE EXONS UNDERLIE ALTERNATIVELY SPLICED ISOFORMS OF THE NA/CA EXCHANGER
    KOFUJI, P
    LEDERER, WJ
    SCHULZE, DH
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1994, 269 (07) : 5145 - 5149
  • [9] Deletion of the alternatively spliced region of the Na+/Ca2+ exchanger, NCX1, reduces functional activity.
    Luo, S
    Neubauer, CF
    Ruknudin, A
    He, S
    Lederer, WJ
    Schulze, DH
    BIOPHYSICAL JOURNAL, 1997, 72 (02) : MP225 - MP225
  • [10] Modulation of intracellular Na+ and Ca2+ induced by the cardiac Na+-Ca2+ exchanger in guinea pig ventricular myocytes
    Yoshida, A
    Noma, A
    Powell, T
    JAPANESE JOURNAL OF PHYSIOLOGY, 2003, 53 (06): : 431 - 442
12345