Reasoning with disposition using DNA tweezers

被引:0
|
作者
Ray, Kumar Sankar [1 ]
Mondal, Mandrita [1 ]
机构
[1] Indian Stat Inst, Elect & Commun Sci Unit, Kolkata 700108, India
关键词
dispositions; commonsense reasoning; chaining syllogism; molecular computing; strand displacement; DNA tweezers; DNA fuel; dispositional modus ponens; usuality; commonsense statement; FUZZY; DISPLACEMENT;
D O I
10.1504/IJBIC.2012.049890
中图分类号
TP18 [人工智能理论];
学科分类号
081104 ; 0812 ; 0835 ; 1405 ;
摘要
In this paper, we consider dynamic DNA devices called DNA tweezers whose operation is based on the mechanism of DNA strand displacement. We show how the systematic use of this simple but robust mechanism makes it possible to produce a DNA-fuelled molecular machine for reasoning with dispositions which are essential ingredients of commonsense of an individual. A biochemical reaction on DNA strands is used to activate DNA tweezers for reasoning with dispositions taken from the commonsense-based knowledge base. The dispositions are basically propositions that are preponderantly but not necessarily always true. The concept of dispositionality is closely related to the notion of usuality which provides a computational framework for commonsense reasoning. As human perception is usually represented in a vague qualitative fashion, we consider fuzzy set as one tool of engineering and try to mimic human intelligence of reasoning based on perception. Since childhood, an individual perceives the world around him/her and accordingly makes several commonsense-based judgements which are essentially reasoning with dispositions.
引用
收藏
页码:302 / 318
页数:17
相关论文
共 50 条
  • [31] Exploring the binding kinetics of chemotherapeutic mitoxantrone to DNA using optical tweezers
    Ferreira, Aaron J.
    Beeloo, Helena K.
    Paramanathan, Thayaparan
    BIOPHYSICAL JOURNAL, 2024, 123 (03) : 225A - 226A
  • [32] Disposition of Malayan People. Straight Reasoning
    Schmidt, P. W.
    ANTHROPOS, 1919, 14-15 (4-6) : 1151 - 1159
  • [33] Narrow gap DNA tweezers for short DNA molecules
    Hosogi, M
    Hashiguch, G
    Asao, F
    Yamamoto, J
    Goda, T
    Hirano, K
    Baba, Y
    Kakushima, K
    Fujita, H
    OPTOMECHATRONIC MICRO/NANO COMPONENTS, DEVICES, AND SYSTEMS, 2004, 5604 : 118 - 125
  • [34] Nanomechanics of DNA-Binders to DNA by Magnetic Tweezers
    Wang, Ying
    Kreft, Dennis
    Sischka, Andy
    Walhorn, Volker
    Toensing, Katja
    Anselmetti, Dario
    BIOPHYSICAL JOURNAL, 2018, 114 (03) : 352A - 352A
  • [35] Improvements for Manipulating DNA with Optical Tweezers
    朱春丽
    李静
    Chinese Physics Letters, 2015, (10) : 174 - 177
  • [36] Improvements for Manipulating DNA with Optical Tweezers
    朱春丽
    李静
    Chinese Physics Letters, 2015, 32 (10) : 174 - 177
  • [37] Stretching DNA with optical tweezers.
    Wang, MD
    Yin, H
    Landick, R
    Gelles, J
    Block, SM
    BIOPHYSICAL JOURNAL, 1996, 70 (02) : SUP63 - SUP63
  • [38] DNA Zipper-Based Tweezers
    Landon, Preston B.
    Ramachandran, Srinivasan
    Gillman, Alan
    Gidron, Timothy
    Yoon, Dosuk
    Lal, Ratnesh
    LANGMUIR, 2012, 28 (01) : 534 - 540
  • [39] Probing DNA Stiffness with Magnetic Tweezers
    Shao, Qing
    Goyal, Sachin
    Finzi, Laura
    Dunlap, David D.
    BIOPHYSICAL JOURNAL, 2011, 100 (03) : 75 - 75
  • [40] Exploring the structural dynamics of DNA using fluorescence polarization microscopy and optical tweezers
    Backer, Adam S.
    King, Graeme A.
    Biebricher, Andreas S.
    Shepherd, Jack
    Noy, Agnes
    Leake, Mark C.
    Heller, Iddo
    Wuite, Gijs J.
    Peterman, Erwin J.
    BIOPHYSICAL JOURNAL, 2022, 121 (03) : 277A - 278A