Reasoning with disposition using DNA tweezers

被引:0
|
作者
Ray, Kumar Sankar [1 ]
Mondal, Mandrita [1 ]
机构
[1] Indian Stat Inst, Elect & Commun Sci Unit, Kolkata 700108, India
关键词
dispositions; commonsense reasoning; chaining syllogism; molecular computing; strand displacement; DNA tweezers; DNA fuel; dispositional modus ponens; usuality; commonsense statement; FUZZY; DISPLACEMENT;
D O I
10.1504/IJBIC.2012.049890
中图分类号
TP18 [人工智能理论];
学科分类号
081104 ; 0812 ; 0835 ; 1405 ;
摘要
In this paper, we consider dynamic DNA devices called DNA tweezers whose operation is based on the mechanism of DNA strand displacement. We show how the systematic use of this simple but robust mechanism makes it possible to produce a DNA-fuelled molecular machine for reasoning with dispositions which are essential ingredients of commonsense of an individual. A biochemical reaction on DNA strands is used to activate DNA tweezers for reasoning with dispositions taken from the commonsense-based knowledge base. The dispositions are basically propositions that are preponderantly but not necessarily always true. The concept of dispositionality is closely related to the notion of usuality which provides a computational framework for commonsense reasoning. As human perception is usually represented in a vague qualitative fashion, we consider fuzzy set as one tool of engineering and try to mimic human intelligence of reasoning based on perception. Since childhood, an individual perceives the world around him/her and accordingly makes several commonsense-based judgements which are essentially reasoning with dispositions.
引用
收藏
页码:302 / 318
页数:17
相关论文
共 50 条
  • [1] Determining the physical properties of DNA in DNA microarrays using optical tweezers
    McDonald, ME
    BIOPHYSICAL JOURNAL, 2005, 88 (01) : 569A - 570A
  • [2] Microrheology of concentrated DNA solutions using optical tweezers
    Rajkumar, Arun S.
    Ali, B. M. Jaffar
    BULLETIN OF MATERIALS SCIENCE, 2008, 31 (03) : 381 - 386
  • [3] Stretching short DNA tethers using optical tweezers
    Reihani, Nader
    Bosanac, Lana
    Hansen, Thomas M.
    Oddershede, Lene B.
    OPTICAL TRAPPING AND OPTICAL MICROMANIPULATION III, 2006, 6326
  • [4] Exploring the binding of mitoxantrone to DNA using optical tweezers
    Patel, Karan R.
    Paramanathan, Thayaparan
    BIOPHYSICAL JOURNAL, 2023, 122 (03) : 75A - 75A
  • [5] Microrheology of concentrated DNA solutions using optical tweezers
    Arun S. Rajkumar
    B. M. Jaffar Ali
    Bulletin of Materials Science, 2008, 31
  • [6] Using optical tweezers to study the DNA unwinding dynamics of a processive DNA polymerase
    Morin, J. A.
    Cao, F. J.
    Valpuesta, J. M.
    Carrascosa, J. L.
    Salas, M.
    Ibarra, B.
    FEBS JOURNAL, 2012, 279 : 512 - 512
  • [7] Exploring the Doxorubicin-Dna Interaction by Dna Stretching using Optical Tweezers
    Ells, Zachary
    Dolle, Brian
    Rouzina, Ioulia F.
    Williams, Mark C.
    Paramanathan, Thayaparan
    BIOPHYSICAL JOURNAL, 2021, 120 (03) : 362A - 362A
  • [8] Probing the Binding Mechanism of DNA Polymerase Kappa to DNA using Optical Tweezers
    Watts, Joshua
    Lone, Samer
    Paramanathan, Thayaparan
    BIOPHYSICAL JOURNAL, 2020, 118 (03) : 73A - 74A
  • [9] Belief does not entail a reasoning disposition
    Simon Wimmer
    Synthese, 2021, 199 : 14975 - 14991
  • [10] Protein-DNA Interactions Studies using Magnetic Tweezers
    Wiggin, Matthew J.
    Dekker, Nynke
    BIOPHYSICAL JOURNAL, 2010, 98 (03) : 593A - 593A