The late stage of autophagy: cellular events and molecular regulation

被引：39
|
作者：
Tong, Jingjing [1 ,2 ]
Yan, Xianghua [2 ]
Yu, Li [1 ]
机构：
[1] Tsinghua Univ, Sch Life Sci, State Key Lab Biomembrane & Membrane Biotechnol, Beijing 100084, Peoples R China
[2] Huazhong Agr Univ, Coll Anim Sci & Technol, Wuhan 430070, Peoples R China
来源：
PROTEIN & CELL | 2010年 / 1卷 / 10期
关键词：
autophagy; autophagosome; lysosome; fusion; degradation;
D O I：
10.1007/s13238-010-0121-z
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Autophagy is an intracellular degradation system that delivers cytoplasmic contents to the lysosome for degradation. It is a "self-eating" process and plays a "house-cleaner" role in cells. The complex process consists of several sequential steps-induction, autophagosome formation, fusion of lysosome and autophagosome, degradation, efflux transportation of degradation products, and autophagic lysosome reformation. In this review, the cellular and molecular regulations of late stage of autophagy, including cellular events after fusion step, are summarized.
引用
收藏
页码：907 / 915
页数：9
相关论文
共 50 条
  • [31] CELLULAR AND MOLECULAR BIOLOGICAL EVENTS AT THE IMPLANT INTERFACE
    BAGAMBISA, FB
    KAPPERT, HF
    SCHILLI, W
    JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY, 1994, 22 (01): : 12 - 17
  • [32] Molecular and cellular events in early thymocyte development
    Rodewald, HR
    Fehling, HJ
    ADVANCES IN IMMUNOLOGY, VOL 69, 1998, 69 : 1 - 112
  • [33] MOLECULAR AND CELLULAR EVENTS OF SELF-INCOMPATIBILITY
    GAUDE, T
    DUMAS, C
    INTERNATIONAL REVIEW OF CYTOLOGY-A SURVEY OF CELL BIOLOGY, 1987, 107 : 333 - 366
  • [34] Pathogenesis of pulmonary emphysema cellular and molecular events
    Di Petta, Antonio
    EINSTEIN-SAO PAULO, 2010, 8 (02): : 248 - 251
  • [35] CELLULAR AND MOLECULAR ASPECTS OF EARLY EVENTS IN NEUROGENESIS
    DUPRAT, AM
    ARCHIVES D ANATOMIE MICROSCOPIQUE ET DE MORPHOLOGIE EXPERIMENTALE, 1986, 75 (03): : 178 - 178
  • [36] Cellular and molecular events in reparative dentinogenesis.
    Sherman, DR
    Cavender, A
    Bronckers, A
    Baumgardner, K
    D'Souza, RN
    JOURNAL OF DENTAL RESEARCH, 1998, 77 : 199 - 199
  • [37] Molecular And Cellular Regulation Of Cardiolipin Uptake
    Waltenbaugh, A. K.
    Poe, S.
    Chen, B. B.
    Ray, P.
    Mallampalli, R. K.
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2011, 183
  • [38] Cellular and molecular regulation of muscle regeneration
    Chargé, SBP
    Rudnicki, MA
    PHYSIOLOGICAL REVIEWS, 2004, 84 (01) : 209 - 238
  • [39] Molecular and cellular regulation of thermogenic fat
    Wang, Cuihua
    Wang, Xianju
    Hu, Wenxiang
    FRONTIERS IN ENDOCRINOLOGY, 2023, 14
  • [40] Cellular regulation and molecular interactions of the ferritins
    K. J. Hintze
    E. C. Theil
    Cellular and Molecular Life Sciences, 2006, 63
12345