The late stage of autophagy: cellular events and molecular regulation

被引：39
|
作者：
Tong, Jingjing [1 ,2 ]
Yan, Xianghua [2 ]
Yu, Li [1 ]
机构：
[1] Tsinghua Univ, Sch Life Sci, State Key Lab Biomembrane & Membrane Biotechnol, Beijing 100084, Peoples R China
[2] Huazhong Agr Univ, Coll Anim Sci & Technol, Wuhan 430070, Peoples R China
来源：
PROTEIN & CELL | 2010年 / 1卷 / 10期
关键词：
autophagy; autophagosome; lysosome; fusion; degradation;
D O I：
10.1007/s13238-010-0121-z
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Autophagy is an intracellular degradation system that delivers cytoplasmic contents to the lysosome for degradation. It is a "self-eating" process and plays a "house-cleaner" role in cells. The complex process consists of several sequential steps-induction, autophagosome formation, fusion of lysosome and autophagosome, degradation, efflux transportation of degradation products, and autophagic lysosome reformation. In this review, the cellular and molecular regulations of late stage of autophagy, including cellular events after fusion step, are summarized.
引用
收藏
页码：907 / 915
页数：9
相关论文
共 50 条
  • [1] The late stage of autophagy: cellular events and molecular regulation
    Jingjing Tong
    Xianghua Yan
    Li Yu
    Protein & Cell, 2010, 1 (10) : 907 - 915
  • [2] Molecular regulation of mitochondrial autophagy and cellular fate
    Ma, Kaili
    Wu, Hao
    Liu, Lei
    Zhu, Yushan
    Chen, Quan
    FREE RADICAL BIOLOGY AND MEDICINE, 2021, 165
  • [3] Autophagy: cellular and molecular mechanisms
    Glick, Danielle
    Barth, Sandra
    Macleod, Kay F.
    JOURNAL OF PATHOLOGY, 2010, 221 (01): : 3 - 12
  • [4] Molecular mechanism and regulation of autophagy
    Ya-ping Yang
    Zhong-qin Liang
    Zhen-lun Gu
    Zheng-hong Qin
    Acta Pharmacologica Sinica, 2005, 26 : 1421 - 1434
  • [5] Molecular mechanism and regulation of autophagy
    Ya-ping YANG~2 Zhong-qin LIANG~2 Zhen-lun GU~2 Zheng-hong QIN~(2
    ActaPharmacologicaSinica, 2005, (12) : 1421 - 1434
  • [6] Molecular mechanism and regulation of autophagy
    Yang, YP
    Liang, ZQ
    Gu, ZL
    Qin, ZH
    ACTA PHARMACOLOGICA SINICA, 2005, 26 (12) : 1421 - 1434
  • [7] Cellular and molecular mechanism for secretory autophagy
    Kimura, Tomonori
    Jia, Jingyue
    Claude-Taupin, Aurore
    Kumar, Suresh
    Choi, Seong Won
    Gu, Yuexi
    Mudd, Michal
    Dupont, Nicolas
    Jiang, Shanya
    Peters, Ryan
    Farzam, Farzin
    Jain, Ashish
    Lidke, Keith A.
    Adams, Christopher M.
    Johansen, Terje
    Deretic, Vojo
    AUTOPHAGY, 2017, 13 (06) : 1084 - 1085
  • [8] Autophagy pathway: Cellular and molecular mechanisms
    Yu, Li
    Chen, Yang
    Tooze, Sharon A.
    AUTOPHAGY, 2018, 14 (02) : 207 - 215
  • [9] CELLULAR AND MOLECULAR EVENTS OF INFLAMMATION
    JACKSON, EM
    JOURNAL OF TOXICOLOGY-CUTANEOUS AND OCULAR TOXICOLOGY, 1984, 3 (04): : 347 - 356
  • [10] MOLECULAR AND CELLULAR EVENTS IN SPERMATOGENESIS
    GROOTEGOED, JA
    BAARENDS, WM
    HENDRIKSEN, PJM
    HOOGERBRUGGE, JW
    SLEGTENHORSTEEGDEMAN, KE
    THEMMEN, APN
    HUMAN REPRODUCTION, 1995, 10 : 10 - 14
12345