Biology of Plasmodium falciparum gametocyte sex ratio and implications in malaria parasite transmission

被引：15
|
作者：
Henry, Noelie Bere [1 ]
Serme, Samuel Sindie [1 ]
Siciliano, Giulia [2 ]
Sombie, Salif [1 ]
Diarra, Amidou [1 ]
Sagnon, N'fale [1 ]
Traore, Alfred S. [3 ]
Sirima, Sodiomon Bienvenu [1 ,4 ]
Soulama, Issiaka [1 ]
Alano, Pietro [2 ]
机构：
[1] Ctr Natl Rech & Format Paludisme, Ouagadougou, Burkina Faso
[2] Ist Super Sanita, Dipartimento Malattie Infett, Rome, Italy
[3] Univ Joseph Ki Zerbo, Ouagadougou, Burkina Faso
[4] Grp Rech Act Sante, Ouagadougou, Burkina Faso
来源：
MALARIA JOURNAL | 2019年 / 18卷 / 1期
关键词：
Malaria; Plasmodium falciparum; Gametocyte; Transmission; Sex ratio; Antimalarial drugs; STAGE-SPECIFIC PROTEIN; SYNCHRONIZED GAMETOCYTES; FERTILITY INSURANCE; FEMALE GAMETOCYTES; RISK-FACTORS; INFECTIVITY; EXPRESSION; COMMITMENT; CARRIAGE; CHILDREN;
D O I：
10.1186/s12936-019-2707-0
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
While significant advances have been made in understanding Plasmodium falciparum gametocyte biology and its relationship with malaria parasite transmission, the gametocyte sex ratio contribution to this process still remains a relevant research question. The present review discusses the biology of sex determination in P. falciparum, the underlying host and parasite factors, the sex specific susceptibility to drugs, the effect of sex ratio dynamics on malaria parasite transmission and the development of gametocyte sex specific diagnosis tools. Despite the inherent differences across several studies and approaches, the emerging picture highlights a potentially relevant contribution of the P. falciparum gametocyte sex ratio in the modulation of malaria parasite transmission. The increasing availability of molecular methods to measure gametocyte sex ratio will enable evaluation of important parameters, such as the impact of drug treatment on gametocyte sex ratio in vitro and in vivo as well as the changes of gametocyte sex ratios in natural infections, key steps towards elucidating how these parameters affect parasite infectiousness to the mosquito vectors.
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收藏
页数：8
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