Hydrazines in the Synthesis of CytotoxicN-Aryl(alkyl)-N-(hexaoxazadispiroalkyl)amines

被引：10
|
作者：
Makhmudiyarova, N. N. [1 ]
Ishmukhametova, I. R. [1 ]
Dzhemileva, L. U. [1 ]
D'yakonov, V. A. [1 ]
Ibragimov, A. G. [1 ]
Dzhemilev, U. M. [1 ]
机构：
[1] Russian Acad Sci IPC RAS, Inst Petrochem & Catalysis, Ufa 450075, Russia
来源：
RUSSIAN JOURNAL OF ORGANIC CHEMISTRY | 2020年 / 56卷 / 05期
基金：
俄罗斯科学基金会;
关键词：
catalysis; recycling; substituted hydrazines; heptaoxadispiroalkanes; N-aryl(alkyl)-N-(hexaoxazadispiroalkanyl)amines; CONFORMERS; TATP;
D O I：
10.1134/S1070428020050115
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient method has been developed for the synthesis ofN-aryl(alkyl)-N-(hexaoxazadispiroalkanyl)amines by the reaction of 3,6-di(spiroalkanyl)-substituted heptaoxacycloundecanes with hydrazine derivatives (3-chlorophenylhydrazine, phenylhydrazine, 2,4-dinitrophenylhydrazine, andtert-butylhydrazine) with Sm-containing catalysts. It was found that amines with macrocyclic spiro-linked azatriperoxide substituents exhibit a high cytotoxic activity against Jurkat, K562, and U937 tumor cell line and normal fibroblast cell line.
引用
收藏
页码：797 / 801
页数：5
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