Microglia in the optic nerve head and the region of parapapillary chorioretinal atrophy in glaucoma

被引:0
|
作者
Neufeld, AH [1 ]
机构
[1] Washington Univ, Sch Med, Dept Ophthalmol & Visual Sci, St Louis, MO 63110 USA
关键词
D O I
暂无
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
Background: Microglia, the macrophages and immune surveillance cells of the central nervous system. are quiescent normally but become activated in injured neural tissue. We have determined the distribution and potential participation of microglia in glaucomatous optic nerve degeneration. Methods: Microglia were localized by immunohistochemistry on paraffin sections of age-matched normal and glaucomatous human eyes obtained within 24 hours after death. Monoclonal and polyclonal antibodies that recognize specific epitopes on microglia and other cell types were localized by immunoperoxidase and immunofluorescence. Results: Stellate cells with thin, ramified processes, positive for HLA-DR and CD45 but negative for glial fibrillary acid protein, were identified as quiescent microglia. These cells were found throughout the normal optic nerve head in the walls of large blood vessels and surrounding capillaries in glial columns and cribriform plates. In glaucomatous eyes with moderate and severe optic nerve head damage, microglia were present as clusters of large ameboid, activated cells in the compressed lamina cribrosa and as formations of concentric circles surrounding blood vessels. In the parapapillary chorioretinal region of glaucomatous optic nerve heads, large, activated microglia were present as single cells or clusters on the termination of the Bruch's membrane. In addition, along the optic nerve/choriocapillaris-scleral interface, activated microglia appeared to form linear arrays near the choriocapillaris vessels. These cells were parenchymal and not in close association with the vasculature. Conclusions: In glaucoma, microglia in the optic nerve head become activated and redistributed. Enlarged, activated microglia appear in the parapapillary chorioretinal region, perhaps due to migration from the disorganized prelaminar and laminar tissue. Strategically positioned microglia may also serve a neuroprotective function in relation to a damaged blood-retinal barrier. The activity of microglia in the parapapillary chorioretinal region in glaucoma may be responsible for some of the biomicroscopic and histological changes that are associated with parapapillary chorioretinal atrophy.
引用
收藏
页码:1050 / 1056
页数:7
相关论文
共 50 条
  • [41] The anatomy and pathophysiology of the optic nerve head in glaucoma
    Burgoyne, CF
    Morrison, JC
    JOURNAL OF GLAUCOMA, 2001, 10 (05) : S16 - S18
  • [42] Mechanical environment of the optic nerve head in glaucoma
    Downs, J. Crawford
    Roberts, Michael D.
    Burgoyne, Claude F.
    OPTOMETRY AND VISION SCIENCE, 2008, 85 (06) : 425 - 435
  • [43] OPTIC-NERVE HEAD DRUSEN AND GLAUCOMA
    SAMPLES, JR
    VANBUSKIRK, EM
    SHULTS, WT
    VANDYK, HJL
    ARCHIVES OF OPHTHALMOLOGY, 1985, 103 (11) : 1678 - 1680
  • [44] Coexisting optic nerve head drusen and glaucoma
    Piccone, MR
    Piltz-Seymour, JR
    Shin, D
    OPHTHALMOLOGY, 1998, 105 (05) : 761 - 762
  • [45] STUDIES OF OPTIC-NERVE HEAD IN GLAUCOMA
    PORTNEY, GL
    WESTERN JOURNAL OF MEDICINE, 1975, 122 (03): : 240 - 241
  • [46] Anterior Optic Nerve Head Perfusion is Dependent on Adjacent Parapapillary Choroidal perfusion
    Lee, Kyoung Min
    Kim, Joon Mo
    Lee, Eun Ji
    Kim, Tae-Woo
    SCIENTIFIC REPORTS, 2019, 9 (1)
  • [47] Optic nerve head anatomy in myopia and glaucoma, including parapapillary zones alpha, beta, gamma and delta: Histology and clinical features
    Wang, Ya Xing
    Panda-Jonas, Songhomitra
    Jonas, Jost B.
    PROGRESS IN RETINAL AND EYE RESEARCH, 2021, 83
  • [48] Anterior Optic Nerve Head Perfusion is Dependent on Adjacent Parapapillary Choroidal perfusion
    Kyoung Min Lee
    Joon Mo Kim
    Eun Ji Lee
    Tae-Woo Kim
    Scientific Reports, 9
  • [49] Activated microglia in the human glaucomatous optic nerve head
    Yuan, LY
    Neufeld, AH
    JOURNAL OF NEUROSCIENCE RESEARCH, 2001, 64 (05) : 523 - 532
  • [50] Imaging the optic nerve head and nerve fiber layer in glaucoma
    Caprioli, J
    Quigley, H
    GLAUCOMA IN THE NEW MILLENNIUM, PROCEEDINGS, 2003, : 129 - 132