Requirement of the activation-induced deaminase (AID) gene for immunoglobulin gene conversion

被引：361
|
作者：
Arakawa, H [1 ]
Hauschild, J [1 ]
Buerstedde, JM [1 ]
机构：
[1] Heinrich Pette Inst, Dept Cellular Immunol, D-20251 Hamburg, Germany
来源：
SCIENCE | 2002年 / 295卷 / 5558期
关键词：
D O I：
10.1126/science.1067308
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Three phenotypically distinct processes-somatic hypermutation, gene conversion, and switch recombination-remodel the functionally rearranged immunoglobulin (Ig) loci in B cells. Somatic hypermutation and switch recombination have recently been shown to depend on the activation-induced deaminase (AID) gene product. Here, we show that the disruption of the AID gene in the chicken B cell line DT40 completely blocks Ig gene conversion and that this block can be complemented by reintroduction of the AID complementary DNA. This demonstrates that the AID master gene controls all B cell-specific modifications of vertebrate Ig genes.
引用
收藏
页码：1301 / 1306
页数：6
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