CSF chemokine levels in relapsing neuromyelitis optica and multiple sclerosis

被引：59
|
作者：
Narikawa, K
Misu, T
Fujihara, K
Nakashima, I
Sato, S
Itoyama, Y
机构：
[1] Tohoku Univ, Sch Med, Dept Neurol, Sendai, Miyagi 9808574, Japan
[2] Kohnan Hosp, Dept Neurol, Sendai, Miyagi 9828523, Japan
来源：
JOURNAL OF NEUROIMMUNOLOGY | 2004年 / 149卷 / 1-2期
关键词：
relapsing neuromyelitis optica; multiple sclerosis; chemokine;
D O I：
10.1016/j.jneuroim.2003.12.010
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The pathogenesis of relapsing neuromyelitis optica (RNMO) remains unknown. We, for the first time, studied the levels of four chemokines in the cerebrospinal fluid in RNMO with ELISA and compared the data with those in multiple sclerosis (MS) and control. CXCL10/IP-10 and CCL17/TARC were significantly elevated in both RNMO and MS. Conversely, CCL2/MCP-1 was significantly lower in MS, but not in RNMO, than in control. CCL11/Eotaxin was not different between groups. None of the four chemokines studied was significantly different between RNMO and MS. (C) 2004 Elsevier B.V. All rights reserved.
引用
收藏
页码：182 / 186
页数：5
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