Cell type specific gene delivery by lentiviral vectors New options in immunotherapy

被引：14
|
作者：
Zhou, Qi [1 ]
Buchholz, Christian J. [1 ]
机构：
[1] Paul Ehrlich Inst, Langen, Germany
来源：
ONCOIMMUNOLOGY | 2013年 / 2卷 / 01期
关键词：
gene transfer; lentiviral vector; CD8(+) T lymphocytes; tumor; targeting;
D O I：
10.4161/onci.22566
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Many cells of the immune system are defined by distinct surface markers, which can be used to restrict gene delivery exclusively to a cell type of choice. This article explains recent findings about a CD8-specific vector that enhances the killing of tumor cells in TCR-based gene transfer strategies.
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页数：3
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