Cross-packaging a vector genome containing densovirus ITR into AAV capsid serotype 2 or 8: possible or not?

被引:0
|
作者
Laugel, M. [1 ]
Roblin, A. [1 ]
Audrain, C. [1 ]
Cheve, C. [1 ]
Menard, L. [1 ]
Blouin, V. [1 ]
Mevel, M. [1 ]
Adjali, O. [1 ]
Penaud-Budloo, M. [1 ]
机构
[1] INSERM, UMR 1089, Paris, France
关键词
D O I
暂无
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
P098
引用
收藏
页码:A49 / A50
页数:2
相关论文
共 20 条
  • [1] Optimization of AAV Vector Design to Reduce Cross-Packaging and ITR Promoter Activity
    Guggenbiller, Matthew John
    Taylor, Noah
    Harper, Scott Q.
    MOLECULAR THERAPY, 2023, 31 (04) : 664 - 664
  • [2] A Novel Proviral Plasmid Reduces Cross-Packaging and ITR Promoter Activity in AAV Vector Preparations
    Taylor, Noah
    Guggenbiller, Matthew John
    Mistry, Pranali
    Harper, Scott Q.
    MOLECULAR THERAPY, 2024, 32 (04) : 14 - 15
  • [3] A self-complementary AAV proviral plasmid that reduces cross-packaging and ITR promoter activity in AAV vector preparations
    Taylor, Noah K.
    Guggenbiller, Matthew J.
    Mistry, Pranali P.
    King, Oliver D.
    Harper, Scott Q.
    MOLECULAR THERAPY METHODS & CLINICAL DEVELOPMENT, 2024, 32 (03)
  • [4] Cross-Packaging and Capsid Mosaic Formation in Multiplexed AAV Libraries
    Schmit, Pauline F.
    Pacouret, Simon
    Zinn, Eric
    Telford, Elizabeth
    Nicolaou, Fotini
    Broucque, Frederic
    Andres-Mateos, Eva
    Xiao, Ru
    Penaud-Budloo, Magalie
    Bouzelha, Mohammed
    Jaulin, Nicolas
    Adjali, Oumeya
    Ayuso, Eduard
    Vandenberghe, Luk H.
    MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT, 2020, 17 : 107 - 121
  • [5] Production of low cross-packaging AAV capsid libraries in insect cells
    Bosma, B.
    Yebra-Pimentel, E. Santidrian
    van der Zon, T.
    Momchev, L.
    Kusuma, A.
    HUMAN GENE THERAPY, 2024, 35 (3-4) : A103 - A104
  • [6] Cross-packaging of a single adeno-associated virus (AAV) type 2 vector genome into multiple AAV serotypes enables transduction with broad specificity
    Rabinowitz, JE
    Rolling, F
    Li, CW
    Conrath, H
    Xiao, WD
    Xiao, X
    Samulski, RJ
    JOURNAL OF VIROLOGY, 2002, 76 (02) : 791 - 801
  • [7] Alteration of AAV Capsid Lumenal Residues to Expand Vector Genome Packaging Capacity
    Tiffany, Matthew
    Pekrun, Katja
    Zhang, Feijie
    Kay, Mark A.
    MOLECULAR THERAPY, 2018, 26 (05) : 191 - 191
  • [8] Production and Characterization of Infectious Snake AAV Vectors with a Cross-Packaged AAV2-ITR Genome
    Tanaka, Yoshinori
    Takahama, Kazuhiro
    Sairavi, Anusha
    Nakai, Hiroyuki
    MOLECULAR THERAPY, 2018, 26 (05) : 182 - 182
  • [9] Analysis of vector genome integration sites in various tissues following systemic administration of AAV serotype 8 vector in mice
    Inagaki, K
    Wu, XL
    Fuess, S
    Storm, TA
    Kay, MA
    Nakai, H
    JOURNAL OF GENE MEDICINE, 2006, 8 (03): : 391 - 391
  • [10] Kinetics of Adeno-Associated Virus Serotype 2 (AAV2) and AAV8 Capsid Antigen Presentation In Vivo Are Identical
    He, Yi
    Weinberg, Marc S.
    Hirsch, Matt
    Johnson, Mark C.
    Tisch, Roland
    Samulski, R. Jude
    Li, Chengwen
    HUMAN GENE THERAPY, 2013, 24 (05) : 545 - 553