Solid probe assisted nanoelectrospray ionization mass spectrometry for biological tissue diagnostics

被引：24

作者：

Mandal, Mridul Kanti ^{[1
]}

Yoshimura, Kentaro ^{[2
]}

Saha, Subhrakanti ^{[1
]}

Ninomiya, Satoshi ^{[3
]}

Rahman, Md. Obaidur ^{[1
]}

Yu, Zhan ^{[4
]}

Chen, Lee Chuin ^{[3
]}

Shida, Yasuo ^{[1
]}

Takeda, Sen ^{[2
]}

Nonami, Hiroshi ^{[5
]}

Hiraoka, Kenzo ^{[1
]}

机构：

[1] Univ Yamanashi, Clean Energy Res Ctr, Kofu, Yamanashi 4008511, Japan

[2] Univ Yamanashi, Interdisciplinary Grad Sch Med & Engn, Dept Anat & Cell Biol, Chuo Ku, Yamanashi 4093898, Japan

[3] Univ Yamanashi, Interdisciplinary Grad Sch Med & Engn, Kofu, Yamanashi 4008511, Japan

[4] Shenyang Normal Univ, Coll Chem & Biol, Shenyang 110034, Peoples R China

[5] Ehime Univ, Fac Agr, Plant Biophys Biochem Res Lab, Matsuyama, Ehime 790, Japan

来源：

ANALYST | 2012年 / 137卷 / 20期

基金：

日本科学技术振兴机构;

关键词：

DESORPTION ELECTROSPRAY-IONIZATION; VIVO;

D O I：

10.1039/c2an36006c

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

To perform remote and direct sampling for mass spectrometry, solid probe assisted nanoelectrospray ionization (SPA-nanoESI) has been newly developed. After capturing the sample on the tip of the needle by sticking it to the biological tissue, the needle was inserted into the solvent-preloaded nanoESI capillary from the backside. NanoESI gave abundant ion signals for human kidney tissues and the liver of a living mouse. The method is easy to operate and versatile because any biological specimen could be sampled away from the mass spectrometer. Minimal invasiveness is another merit of this method.

引用

页码：4658 / 4661

页数：4

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