Effect of VEGF, P53 and telomerase on angiogenesis of gastric carcinoma tissue

被引：25
|
作者：
Yu, Yan-Fang [1 ]
Zhang, Yong [1 ]
Shen, Na [1 ]
Zhang, Rui-Ying [1 ]
Lu, Xin-Qing [1 ]
机构：
[1] Hebei Univ Engn, Affiliated Hosp, Handan 056002, Hebei, Peoples R China
来源：
ASIAN PACIFIC JOURNAL OF TROPICAL MEDICINE | 2014年 / 7卷 / 04期
关键词：
VEGF; P53; Telomerase; Angiogenesis; Gastric carcinoma; LYMPH-NODE METASTASIS; GROWTH-FACTOR-C; COLORECTAL-CANCER; BREAST-CANCER; EXPRESSION; LYMPHANGIOGENESIS; PROGNOSIS;
D O I：
10.1016/S1995-7645(14)60041-9
中图分类号：
R1 [预防医学、卫生学];
学科分类号：
1004 ; 120402 ;
摘要：
Objective: To investigate the effect of vascular endothelial growth factor (VEGF), P53 and telomerase on angiogenesis in gastric carcinoma tissue. Methods: A total of 95 surgical resection samples of gastric cancer tissue after pathological diagnosis are collected to observe the VEGF, P53 and telomerase expression using immunohistochemical methods. Relationship between their expression and its influence on angiogenesis in gastric carcinoma tissue were analyzed. Results: Microvascular density (MVD) and the expression of VEGF, P53 and telomerase were positively correlated. Expression of VEGF and P53 protein were related to tumor type and lymph metastasis, and also a correlation was observed between P53 and VEGF. The telomerase expression had no correlation with VEGF, and P53. Conclusions: VEGF angiogenesis has a angiogenesis promoting effect on gastric cancer tissue development and plays an important role in tumor generation and metastasis. Mutant P53 promotes the tumor angiogenesis generation by adjusting VEGF. Telomerase has a certain role in promoting activity of angiogenesis through different way rather than P53.
引用
收藏
页码：293 / 296
页数：4
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