Synthesis and Neurotropic Activity of New Condensed Pyrido[3',2':4,5]furo[3,2-d]-pyrimidine Derivatives

被引：3
|
作者：
Dabaeva, V. V. [1 ]
Bagdasaryan, M. R. [1 ]
Noravyan, A. S. [1 ]
Nazaryan, I. M. [1 ]
Akopyan, A. G. [1 ]
Tadevosyan, A. A. [1 ]
机构：
[1] Natl Acad Sci Republ Armenia, Sci Tech Ctr Organ & Pharmaceut Chem, AL Mndzhoyan Inst Fine Organ Chem, Yerevan, Armenia
来源：
PHARMACEUTICAL CHEMISTRY JOURNAL | 2013年 / 47卷 / 03期
关键词：
Synthesis, pyrido[3 ',2 ':4,5]furo[3,2-d]pyrimidine; anticonvulsive activity;
D O I：
10.1007/s11094-013-0911-8
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Methods for preparing derivatives of a new heterosystem - pyrano-[3'',4'':5',6']pyrido[3',2':4,5]furo[3,2-d]pyrimidine - were developed on the basis of 2-oxo-3-cyano derivatives of pyrano[4,3-b]pyridine. The anticonvulsive activity of the compounds synthesized here was studied. These had weak anticorasol properties, which were not accompanied by sedative or myorelaxant effects, which is a positive property of this class of compounds.
引用
收藏
页码：135 / 138
页数：4
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