Psychiatric outcomes 10 years after treatment with antidepressants or anxiolytics

被引:7
|
作者
Colman, Ian [1 ]
Croudace, Tim J. [2 ]
Wadsworth, Michael E. J. [3 ]
Kuh, Diana [3 ]
Jones, Peter B. [2 ]
机构
[1] Univ Alberta, Sch Publ Hlth, Dept Publ Hlth Sci, Edmonton, AB T6G 2G3, Canada
[2] Univ Cambridge, Dept Psychiat, Cambridge, England
[3] UCL, Sch Med, MRC Natl Survey Hlth & Dev, Dept Epidemiol & Publ Hlth, London W1N 8AA, England
基金
英国医学研究理事会; 美国国家卫生研究院;
关键词
D O I
10.1192/bjp.bp.107.043430
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Background Antidepressants and anxiolytics have demonstrated short-term efficacy, however, little is known about the long-term effectiveness of these drugs. Aims To investigate long-term psychiatric outcomes following antidepressant and/or anxiolytic use during an episode of mental disorder in mid-life. Method Members of the 1946 British birth cohort were assessed for symptoms of depression and anxiety at age 43. Among 157 with mental disorder, those using antidepressants and/or anxiolytics were compared with those not using medications on psychiatric outcomes at age 53. Results Use of antidepressants or anxiolytics was associated with a lower prevalence of mental disorder at age 53 (odds ratio (OR)=0.3, 95% Cl 0.1-1.0) after adjustment for eight variables in a propensity-for-treatment analysis. Only 24% of those being treated with medications at age 43 were still using them at 53. Conclusions Use of antidepressants or anxiolytics during an episode of mental disorder may have long-term beneficial effects on mental health. This may be because of a demonstrated willingness to seek help rather than long-term maintenance therapy.
引用
收藏
页码:327 / 331
页数:5
相关论文
共 50 条
  • [41] Erratum to: Effectiveness of agalsidase alfa enzyme replacement in Fabry disease: cardiac outcomes after 10 years’ treatment
    Christoph Kampmann
    Amandine Perrin
    Michael Beck
    Orphanet Journal of Rare Diseases, 11
  • [42] Prediction of drinking outcomes for male alcoholics after 10 to 14 years
    Powell, BJ
    Landon, JF
    Cantrell, PJ
    Penick, EC
    Nickel, EJ
    Liskow, BI
    Coddington, TM
    Campbell, JL
    Dale, TM
    Vance, MD
    Rice, AS
    ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, 1998, 22 (03) : 559 - 566
  • [43] Risk for use of antidepressants, anxiolytics, and hypnotics in partners of glioma patientsA nationwide study covering 19years of prescriptions
    Jansson, Maria R. N.
    von Heymann-Horan, Annika
    Rasmussen, Birthe K.
    Albieri, Vanna
    Frederiksen, Kirsten
    Suppli, Nis
    Dalton, Susanne O.
    Johansen, Christoffer
    Bidstrup, Pernille E.
    PSYCHO-ONCOLOGY, 2018, 27 (08) : 1930 - 1936
  • [44] Effectiveness of agalsidase alfa enzyme replacement in Fabry disease: cardiac outcomes after 10 years' treatment (vol 10, 125, 2015)
    Kampmann, Christoph
    Perrin, Amandine
    Beck, Michael
    ORPHANET JOURNAL OF RARE DISEASES, 2016, 11
  • [45] MEDICAL OUTCOMES OF HIV plus INDIVIDUALS TWO YEARS AFTER INITIATING PSYCHIATRIC SERVICES
    Brown, Jennifer L.
    Stepleman, Lara M.
    Bottonari, Kathryn A.
    ANNALS OF BEHAVIORAL MEDICINE, 2011, 41 : S64 - S64
  • [46] Outcomes of child psychiatric treatment
    Lundh, A.
    Forsman, M.
    Serlachius, E.
    Lichtenstein, P.
    Landen, M.
    ACTA PSYCHIATRICA SCANDINAVICA, 2013, 128 (01) : 34 - 44
  • [47] SKELETAL PAIN 10 YEARS AFTER TREATMENT OF OVARIAN CANCER
    FLINK, EB
    JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1970, 212 (06): : 1074 - &
  • [48] Outcome at 10 years after treatment for adolescent idiopathic scoliosis
    Andersen, MO
    Christensen, SB
    Thomsen, K
    SPINE, 2006, 31 (03) : 350 - 354
  • [49] FAMILY COPING WITH PEDIATRIC LEUKEMIA - 10 YEARS AFTER TREATMENT
    KUPST, MJ
    NATTA, MB
    RICHARDSON, CC
    SCHULMAN, JL
    LAVIGNE, JV
    DAS, L
    JOURNAL OF PEDIATRIC PSYCHOLOGY, 1995, 20 (05) : 601 - 617
  • [50] Thyroid dysfunction in laryngectomees- 10 years after treatment
    Ho, Ambrose Chung-Wai
    Ho, Wai-Kuen
    Lam, Paul Kin-Yip
    Yuen, Anthony Po-Wing
    Wei, William Ignace
    HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, 2008, 30 (03): : 336 - 340