Clinical Trial Highlights - Aerobic Exercise for Parkinson's Disease

被引：5

作者：

Schootemeijer, Sabine ^{[1
]}

Darweesh, Sirwan K. L. ^{[1
]}

de Vries, Nienke M. ^{[1
]}

机构：

[1] Radboud Univ Nijmegen, Ctr Expertise Parkinson & Movement Disorders, Dept Neurol, Med Ctr, POB 9101, NL-6500 HB Nijmegen, Netherlands

来源：

JOURNAL OF PARKINSONS DISEASE | 2022年 / 12卷 / 08期

关键词：

TREADMILL EXERCISE; NEUROPLASTICITY; MOTOR; LIFE;

D O I：

10.3233/JPD-229006

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Converging lines of evidence suggest that aerobic exercise impacts Parkinson's disease (PD) motor symptoms and might slow it's progression. We provide an overview of the ongoing randomized clinical trials (RCTs) on aerobic exercise in PD. We found six RCTs with sample sizes between 28 and 370 and a follow-up between 8 weeks and 18 months. PD motor symptoms is mostly used as primary outcome while various secondary outcomes are reported. We need more trials that use both clinical endpoints and markers of neuroplasticity, and provide insight into the optimal exercise mode, duration and intensity.

引用

页码：2297 / 2306

页数：10

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