Combined EGFR/ALK Expression Analysis in Laryngeal Squamous Cell Carcinoma

被引：8

作者：

Politi, Anastasia ^{[1
]}

Tsiamb, Evangelos ^{[2
]}

Mastronikolis, Nicholas S. ^{[3
]}

Peschos, Dimitrios ^{[4
]}

Asproudis, Ioannis ^{[5
]}

Kyrodimos, Efthymios ^{[6
]}

Armata, Ilianna E. ^{[7
]}

Chrysovergis, Aristeidis ^{[6
]}

Asimakopoulos, Asimakis ^{[8
]}

Papanikolaou, Vasileios S. ^{[6
]}

Batistatou, Anna ^{[9
]}

Ragos, Vasileios ^{[10
]}

机构：

[1] Univ Ioannina, Med Sch, Dept Oncol, Ioannina, Greece

[2] 401 GAH, Dept IHC & Mol Biol, Athens, Greece

[3] Univ Patras, Med Sch, ENT Dept, Patras, Greece

[4] Univ Ioannina, Med Sch, Dept Physiol, Ioannina, Greece

[5] Univ Ioannina, Med Sch, Dept Ophthalmol, Ioannina, Greece

[6] Natl & Kapodistrian Univ Athens, Hippokrat Hosp, IST ENT Dept, Athens, Greece

[7] Cambridge Univ Hosp, Med Sch, Cambridge, England

[8] Luxembourg Hosp Ctr, ENT Dept, Luxembourg, Luxembourg

[9] Univ Ioannina, Med Sch, Dept Pathol, Ioannina, Greece

[10] Univ Ioannina, Med Sch, Dept Maxillofacial, Ioannina, Greece

来源：

IN VIVO | 2019年 / 33卷 / 03期

关键词：

Carcinoma; larynx; EGFR; ALK; GROWTH-FACTOR RECEPTOR; CANCER; ALK; NECK; HEAD; MET; SURVIVAL; GENE;

D O I：

10.21873/invivo.11544

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Background/Aim: Epidermal growth factor receptor (EGFR) acts as an oncogene in malignancies. Our aim was to examine the role of combined EGFR/ anaplastic lymphoma kinase (ALK) expression as molecular markers in laryngeal squamous cell carcinoma (LSCC) patients. Materials and Methods: Fifty (n=50) tissue sections derived from twenty-five (n=25) primary LSCCs were analyzed by immunohistochemistry (IHC). Results: EGFR overexpression was observed in 17/25 (68%) cases. Concerning ALK, 23/25 (92%) demonstrated low expression. EGFR expression was associated with grade (p=0.049), whereas ALK expression was correlated with stage (p=0.048). ALK overexpression was detected at advanced-stage EGFR-positive cases. A biphasic EGFR protein expression pattern was observed in five (n=5) LSCC cases, whereas ALK expression was stable in all cases. Conclusion: EGFR overexpression is frequently observed in LSCC combined with low ALK expression. LSCC patients with EGFR/ALK protein overexpression should be eligible for targeted therapeutic strategies.

引用

页码：815 / 819

页数：5

共 50 条

[31] Analysis of microsatellite instability in laryngeal squamous cell carcinoma
Garcia Martinez, Jorge
Perez-Escuredo, Jhudit
Garcia-Carracedo, Dario
Alonso-Guervos, Marta
Suarez-Nieto, Carlos
Luis Llorente-Pendas, Jose
Alvarez-Marcos, Cesar
Hermsen, Mario
ACTA OTORRINOLARINGOLOGICA ESPANOLA, 2012, 63 (02): : 79 - 84
[32] Co-targeting ALK and EGFR parallel signaling in oral squamous cell carcinoma
Gonzales, Cara B.
De La Chapa, Jorge J.
Saikumar, Pothana
Singha, Prajjal K.
Dybdal-Hargreaves, Nicholas F.
Chavez, Jeffery
Horning, Aaron M.
Parra, Jamie
Kirma, Nameer B.
ORAL ONCOLOGY, 2016, 59 : 12 - 19
[33] Efficacy of Targeted Inhibitors in Metastatic Lung Squamous Cell Carcinoma With EGFR or ALK Alterations
Lewis, Whitney E.
Hong, Lingzhi
Mott, Frank E.
Simon, George
Wu, Carol C.
Rinsurongkawong, Waree
Lee, J. Jack
Lam, Vincent K.
Heymach, John V.
Zhang, Jianjun
Le, Xiuning
JTO CLINICAL AND RESEARCH REPORTS, 2021, 2 (11):
[34] EGFR expression in lung squamous cell carcinoma and correlation with prognosis
Vuckovic, L.
Latinovic, Tadic L.
Eri, Z.
Savjak, D.
Nenezic, T.
Vukmirovic, F.
Golubovic, M.
VIRCHOWS ARCHIV, 2009, 455 : 355 - 355
[35] ALK Protein Expression Patterns in Squamous Cell Carcinoma of the Oral Cavity
Chrysovergis, Aristeidis
Papanikolaou, Vasileios
Mastronikolis, Nicholas
Tsiambas, Evangelos
Katsinis, Spyros
Manoli, Arezina
Papouliakos, Sotirios
Ragos, Vasileios
Pantos, Pavlos
Peschos, Dimitrios
Mastronikolis, Stylianos
Fotiades, Panagiotis
Mamoulidis, Panagiotis
Spyropoulou, Despoina
Kyrodimos, Efthymios
IN VIVO, 2022, 36 (03): : 1144 - 1149
[36] EGFR over-expression in squamous cell carcinoma of the penis
Wood, L.
Lavens, N.
Gupta, R.
JOURNAL OF CLINICAL ONCOLOGY, 2008, 26 (15)
[37] ALK expression in metastatic cutaneous squamous cell carcinoma: A pilot study
Lobl, M. B.
Georgesen, C.
Black, J.
Lum, M.
Lauer, S.
Whitley, M. J.
Wysong, A.
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2022, 142 (08) : S142 - S142
[38] Pharmacodiagnostic evaluation of EGFR expression in oral squamous cell carcinoma
Diniz-Freitas, M.
Garcia-Caballero, T.
Antunez-Lopez, J.
Gandara-Rey, J. M.
Garcia-Garcia, A.
ORAL DISEASES, 2007, 13 (03) : 285 - 290
[39] EGFR mutation and protein expression analysis in sinonasal inverted papilloma and squamous cell carcinoma
Cabal, Virginia N.
Menendez, Marta
Potes-Ares, Sira
Vivanco, Blanca
Suarez-Fernandez, Laura
Riobello, Cristina
Garcia-Marin, Rocio
Lopez, Fernando
Luis Llorente, Jose
Hermsen, Mario
CANCER RESEARCH, 2019, 79 (13)
[40] Differential expression of microRNAs in plasma of patients with laryngeal squamous cell carcinoma: potential early-detection markers for laryngeal squamous cell carcinoma
Ayaz, Lokman
Gorur, Aysegul
Yaroglu, Hatice Yildirim
Ozcan, Cengiz
Tamer, Lulufer
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 2013, 139 (09) : 1499 - 1506

← 1 2 3 4 5 →