Combined EGFR/ALK Expression Analysis in Laryngeal Squamous Cell Carcinoma

被引：8

作者：

Politi, Anastasia ^{[1
]}

Tsiamb, Evangelos ^{[2
]}

Mastronikolis, Nicholas S. ^{[3
]}

Peschos, Dimitrios ^{[4
]}

Asproudis, Ioannis ^{[5
]}

Kyrodimos, Efthymios ^{[6
]}

Armata, Ilianna E. ^{[7
]}

Chrysovergis, Aristeidis ^{[6
]}

Asimakopoulos, Asimakis ^{[8
]}

Papanikolaou, Vasileios S. ^{[6
]}

Batistatou, Anna ^{[9
]}

Ragos, Vasileios ^{[10
]}

机构：

[1] Univ Ioannina, Med Sch, Dept Oncol, Ioannina, Greece

[2] 401 GAH, Dept IHC & Mol Biol, Athens, Greece

[3] Univ Patras, Med Sch, ENT Dept, Patras, Greece

[4] Univ Ioannina, Med Sch, Dept Physiol, Ioannina, Greece

[5] Univ Ioannina, Med Sch, Dept Ophthalmol, Ioannina, Greece

[6] Natl & Kapodistrian Univ Athens, Hippokrat Hosp, IST ENT Dept, Athens, Greece

[7] Cambridge Univ Hosp, Med Sch, Cambridge, England

[8] Luxembourg Hosp Ctr, ENT Dept, Luxembourg, Luxembourg

[9] Univ Ioannina, Med Sch, Dept Pathol, Ioannina, Greece

[10] Univ Ioannina, Med Sch, Dept Maxillofacial, Ioannina, Greece

来源：

IN VIVO | 2019年 / 33卷 / 03期

关键词：

Carcinoma; larynx; EGFR; ALK; GROWTH-FACTOR RECEPTOR; CANCER; ALK; NECK; HEAD; MET; SURVIVAL; GENE;

D O I：

10.21873/invivo.11544

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Background/Aim: Epidermal growth factor receptor (EGFR) acts as an oncogene in malignancies. Our aim was to examine the role of combined EGFR/ anaplastic lymphoma kinase (ALK) expression as molecular markers in laryngeal squamous cell carcinoma (LSCC) patients. Materials and Methods: Fifty (n=50) tissue sections derived from twenty-five (n=25) primary LSCCs were analyzed by immunohistochemistry (IHC). Results: EGFR overexpression was observed in 17/25 (68%) cases. Concerning ALK, 23/25 (92%) demonstrated low expression. EGFR expression was associated with grade (p=0.049), whereas ALK expression was correlated with stage (p=0.048). ALK overexpression was detected at advanced-stage EGFR-positive cases. A biphasic EGFR protein expression pattern was observed in five (n=5) LSCC cases, whereas ALK expression was stable in all cases. Conclusion: EGFR overexpression is frequently observed in LSCC combined with low ALK expression. LSCC patients with EGFR/ALK protein overexpression should be eligible for targeted therapeutic strategies.

引用

页码：815 / 819

页数：5

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