Bioactive terpenoids from the Red Sea soft coral Sinularia polydactyla

被引：12
|
作者：
Aboutabl, El-Sayed A. [1 ]
Azzam, Shadia M. [1 ]
Michel, Camilia G. [1 ]
Selim, Nabil M. [1 ]
Hegazy, Mohamed F. [2 ]
Ali, Abdel-Hamid A. M. [3 ]
Hussein, Ahmed A. [4 ]
机构：
[1] Cairo Univ, Dept Pharmacognosy, Giza, Egypt
[2] Natl Res Ctr, Dept Phytochem, Cairo, Egypt
[3] Natl Inst Oceanog & Fisheries, Suez City, Egypt
[4] Univ Western Cape, Dept Chem, Western Cape, South Africa
来源：
NATURAL PRODUCT RESEARCH | 2013年 / 27卷 / 23期
关键词：
Red Sea; Sinularia polydactyla; cembrane diterpene; sterols; cytotoxicity; antimicrobial; CEMBRANOID DITERPENES;
D O I：
10.1080/14786419.2013.805333
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Chemical investigation of an ethyl acetate soluble fraction of Sinularia polydactyla (Ehrenberg) led to the isolation of three known terpenoides, two of them sterols, 24-methylcholestane-3,5,6,25-tetrol 25-monoacetate (1), 24-methylcholestane-5-en-3,25-diol (2), in addition to a cembranoid diterpene, durumolide C (3), for the first time. The cytotoxicity and antimicrobial activities of the ethyl acetate extract and the isolated compounds 1-3 were evaluated in vitro. Durumolide C (3) showed selective cytotoxicity against HepG2 (IC50 1.0g/mL), whereas 24-methylcholestane-3,5,6,25-tetrol 25-monoacetate (1) showed IC50 of 6.1 and 8.2g/mL against Hep2 and HCT human cancer cell lines, respectively.
引用
收藏
页码：2224 / 2226
页数：3
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