Bioactive terpenoids from the Red Sea soft coral Sinularia polydactyla

被引：12

作者：

Aboutabl, El-Sayed A. ^{[1
]}

Azzam, Shadia M. ^{[1
]}

Michel, Camilia G. ^{[1
]}

Selim, Nabil M. ^{[1
]}

Hegazy, Mohamed F. ^{[2
]}

Ali, Abdel-Hamid A. M. ^{[3
]}

Hussein, Ahmed A. ^{[4
]}

机构：

[1] Cairo Univ, Dept Pharmacognosy, Giza, Egypt

[2] Natl Res Ctr, Dept Phytochem, Cairo, Egypt

[3] Natl Inst Oceanog & Fisheries, Suez City, Egypt

[4] Univ Western Cape, Dept Chem, Western Cape, South Africa

来源：

NATURAL PRODUCT RESEARCH | 2013年 / 27卷 / 23期

关键词：

Red Sea; Sinularia polydactyla; cembrane diterpene; sterols; cytotoxicity; antimicrobial; CEMBRANOID DITERPENES;

D O I：

10.1080/14786419.2013.805333

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Chemical investigation of an ethyl acetate soluble fraction of Sinularia polydactyla (Ehrenberg) led to the isolation of three known terpenoides, two of them sterols, 24-methylcholestane-3,5,6,25-tetrol 25-monoacetate (1), 24-methylcholestane-5-en-3,25-diol (2), in addition to a cembranoid diterpene, durumolide C (3), for the first time. The cytotoxicity and antimicrobial activities of the ethyl acetate extract and the isolated compounds 1-3 were evaluated in vitro. Durumolide C (3) showed selective cytotoxicity against HepG2 (IC50 1.0g/mL), whereas 24-methylcholestane-3,5,6,25-tetrol 25-monoacetate (1) showed IC50 of 6.1 and 8.2g/mL against Hep2 and HCT human cancer cell lines, respectively.

引用

页码：2224 / 2226

页数：3

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