Association between CYP1A2 polymorphisms and clozapine-induced adverse reactions in patients with schizophrenia

被引：22
|
作者：
Ferrari, Marco [2 ]
Bolla, Emilio [1 ]
Bortolaso, Paola [1 ]
Callegari, Camilla [1 ]
Poloni, Nicola [1 ]
Lecchini, Sergio [2 ]
Vender, Simone [1 ]
Marino, Franca [2 ]
Cosentino, Marco [2 ]
机构：
[1] Univ Insubria, Dept Clin Med, Sect Psychiat, I-21100 Varese, Italy
[2] Univ Insubria, Dept Clin Med, Sect Clin & Expt Pharmacol, I-21100 Varese, Italy
来源：
PSYCHIATRY RESEARCH | 2012年 / 200卷 / 2-3期
关键词：
Pharmacogenetic; Schizophrenia; Cytochrome; GENETIC-POLYMORPHISM; RESISTANCE;
D O I：
10.1016/j.psychres.2012.07.002
中图分类号：
R749 [精神病学];
学科分类号：
100205 ;
摘要：
We investigated the relationships between common polymorphisms in CYP1A2 (CYP1A2*1C and *1F), CYP1A2-mRNA levels in circulating lymphocytes and clozapine(CLZ)-induced adverse drug reactions (ADRs) in 34 patients. Patients with ADRs had a higher frequency of CYP1A2 low activity allele combinations (8/12; 67%) and lower CYP1A2-mRNA levels than patients without ADRs (6/22; 27%, P=0.019). (C) 2012 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：1014 / 1017
页数：4
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