Bioactive polyhydroxylated steroids from the Hainan soft coral Sinularia depressa Tixier-Durivault

被引：43

作者：

Liang, Lin-Fu ^{[1
]}

Wang, Xu-Jie ^{[1
]}

Zhang, Hai-Yan ^{[1
]}

Liu, Hai-Li ^{[1
]}

Li, Jia ^{[1
]}

Lan, Le-Fu ^{[1
]}

Zhang, Wen ^{[2
]}

Guo, Yue-Wei ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China

[2] Second Mil Med Univ, Sch Pharm, Res Ctr Marine Drugs, Shanghai 200433, Peoples R China

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2013年 / 23卷 / 05期

关键词：

Soft coral; Sinularia depressa; Steroid; Neuroprotective; Antibacterial; PTP1B; MARINE-INVERTEBRATES; LITOPHYTON-VIRIDIS; METABOLITES; NEPHTHEA;

D O I：

10.1016/j.bmcl.2012.12.087

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Two new steroids, (2 beta,3 beta,4 alpha,5 alpha,8 beta)-4-methylergost-24(28)-ene-2,3,8-triol (1) and (3 beta,7 alpha)-24-methyl-7-hydroperoxycholest- 5,24(28)-diene-3-ol (2), together with 13 known analogues (3-15) were isolated from the soft coral Sinularia depressa Tixier-Durivault. The structures of the new compounds were elucidated by detailed spectroscopic analysis and comparison with reported data. In the bioassay in vitro, compounds 3a, 4, and 14 exhibited potent PTP1B inhibitory activity, being similar as that of positive control oleanolic acid. Compound 14 also displayed a notable neuroprotective activity against both amyloid-beta(25-35)-and serum deprivation-induced injuries in SH-SY5Y cells while compound 11 showed a considerable antibacterial activity against Staphylococcus aureus. Preliminary structure-activity relationships of these steroids were discussed. Crown Copyright (C) 2013 Published by Elsevier Ltd. All rights reserved.

引用

页码：1334 / 1337

页数：4

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