Suzuki-Miyaura Cross-Coupling of Potassium Alkoxyethyltrifluoroborates: Access to Aryl/Heteroarylethyloxy Motifs

被引：35

作者：

Fleury-Bregeot, Nicolas ^{[2
]}

Presset, Marc ^{[1
]}

Beaumard, Floriane ^{[2
]}

Colornbel, Virginie ^{[1
]}

Oehlrich, Daniel ^{[1
]}

Rombouts, Frederik ^{[1
]}

Molander, Gary A. ^{[2
]}

机构：

[1] Janssen Pharmaceut, Res & Dev, Neurosci Med Chem, B-2340 Beerse, Belgium

[2] Univ Penn, Dept Chem, Roy & Diana Vagelos Labs, Philadelphia, PA 19104 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2012年 / 77卷 / 22期

基金：

美国国家科学基金会;

关键词：

BOC-PROTECTED AMINOMETHYLTRIFLUOROBORATE; C-H BONDS; CATALYZED BORYLATION; ALKYL-HALIDES; ALKYLBORONIC ESTERS; BORONIC ACID; ARYL; HYDROBORATION; ETHERS; DERIVATIVES;

D O I：

10.1021/jo3021665

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The introduction of an alkoxyethyl moiety onto aromatic substructures has remained a long-standing challenge for synthetic organic chemists. The main reasons are the inherent instability of alkoxyethylmetallic species and the lack of general procedures to access them. A new method utilizing a cross-coupling strategy based on the exceptional properties of organotrifluoroborates has been developed, and the method allows an easy and efficient installation of this unit on a broad range of aryl and heteroaryl bromides.

引用

页码：10399 / 10408

页数：10

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