GluN2A versus GluN2B: twins, but quite different

被引：36
|
作者：
Zhang, Xiao-Min [1 ]
Luo, Jian-Hong [1 ]
机构：
[1] Zhejiang Univ, Zhejiang Prov Key Lab Neurobiol, Key Lab Med Neurobiol, Minist Hlth China,Dept Neurobiol,Sch Med, Hangzhou 310058, Zhejiang, Peoples R China
来源：
NEUROSCIENCE BULLETIN | 2013年 / 29卷 / 06期
基金：
中国国家自然科学基金;
关键词：
N-methyl-D-aspartate receptors; GluN2A; GluN2B; developmental expression; brain distribution; function; trafficking; NR2B-CONTAINING NMDA RECEPTORS; LONG-TERM POTENTIATION; D-ASPARTATE RECEPTOR; ENDOPLASMIC-RETICULUM RETENTION; SYNAPTIC PLASTICITY; SUBUNIT COMPOSITION; MOLECULAR MOTORS; CELL-SURVIVAL; CREB SHUTOFF; NR2; SUBUNITS;
D O I：
10.1007/s12264-013-1336-9
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
N-Methyl-D-aspartate receptors (NMDARs) play vital roles in the central nervous system, as they are primary mediators of Ca2+ influx during synaptic activity. The subunits that compose NMDARs share similar topological structures but are distinct in distribution and pharmacological properties, as well as physiological and pathological functions, which make the NMDAR one of the most complex and elusive ionotropic glutamate receptors. In this review, we focus on GluN2A and GluN2B, the primary NMDAR subunits in the cortex and hippocampus, and discuss their differences in developmental expression, brain distribution, trafficking, and functional properties during neuronal activity.
引用
收藏
页码：761 / 772
页数：12
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