One-Step Synthesis of Isoquinolinone Compounds

被引：1

作者：

Wang, Baoqu ^{[1
]}

Kong, Lingbin ^{[1
]}

Luo, Qin ^{[1
]}

Lin, Jun ^{[1
]}

Yan, Shengjiao ^{[1
]}

机构：

[1] Yunnan Univ, Sch Chem Sci & Technol, Minist Educ, Key Lab Med Chem Nat Resource, Kunming 650091, Yunnan, Peoples R China

来源：

CHINESE JOURNAL OF ORGANIC CHEMISTRY | 2017年 / 37卷 / 11期

基金：

中国国家自然科学基金;

关键词：

environment friendly; atom economy; heterocyclic ketone aminals; isoquinolinones; HETEROCYCLIC KETENE AMINALS; REGIOSELECTIVE SYNTHESIS; DERIVATIVES; CONSTRUCTION;

D O I：

10.6023/cjoc201705038

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A concise and efficiently route for the synthesis of isoquinolinones via one-step reaction of nitro substituted methyl 2-fluorobenzoate 1 and heterocyclic ketone aminals (HKAs, 2) in 1,4-dioxane catalyzed by Cs2CO3 under reflux conditions has been developed. Isoquinolinones 3 were obtained by one-step strategy. This protocol possesses some advantages including readily available starting materials, simple operation and concise synthetic route and so on.

引用

页码：2972 / 2977

页数：6

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