Generation of an induced pluripotent stem cell line KUMCi001-A from CD34+bone marrow cells of a patient with acute lymphoblastic leukemia using human placenta-derived cell conditioned medium

被引：3
|
作者：
Lee, Seung-Jin [1 ,2 ]
Kang, Ka-Won [3 ]
Kim, Ji-Hea [1 ,2 ]
Park, Young [3 ]
Kim, Byung-Soo [1 ,2 ,3 ]
机构：
[1] Korea Univ, Inst Stem Cell Res, Coll Med, Seoul, South Korea
[2] Korea Univ, Grad Sch Med, Dept Biomed & Sci, Seoul, South Korea
[3] Korea Univ, Dept Internal Med, Anam Hosp, Med Ctr, Seoul, South Korea
来源：
STEM CELL RESEARCH | 2020年 / 47卷
关键词：
D O I：
10.1016/j.scr.2020.101913
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Many patients with acute lymphoblastic leukemia (ALL) show relapse post-chemotherapy. Therefore, it is important to develop a human induced pluripotent stem cell (hiPSC) line from ALL cells to verify the pathophysiology. However, the low efficiency of the established reprogramming protocol has hampered the development of ALL hiPSC lines. Our recently reported novel reprogramming method, using human placenta-derived cell conditioned medium (hPCCM), offers a relatively higher efficiency in humanized conditions. Here, we generated an hiPSC line from ALL-derived CD34+ bone marrow cells, using hPCCM for reprogramming. This hiPSC line might be a useful model for studies on ALL.
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页数：4
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