Optimal process/solvent design for ethanol extractive fermentation with cell recycling

被引：13

作者：

Cheng, Hou-Chieh ^{[1
]}

Wang, Feng-Sheng ^{[1
]}

机构：

[1] Natl Chung Cheng Univ, Dept Chem Engn, Chiayi 62102, Taiwan

来源：

BIOCHEMICAL ENGINEERING JOURNAL | 2008年 / 41卷 / 03期

关键词：

ethanol; fermentation; liquid-liquid extraction; optimization; solvent design; hybrid differential evolution;

D O I：

10.1016/j.bej.2008.05.004

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

In this study, the computer-aided process/solvent design is introduced to find an optimal biocompatible solvent and to maximize the ethanol production rate simultaneously for the single- or double-stage extractive fermentation process with cell recycling. Such a process/solvent design problem is formulated as a mixed-integer nonlinear programming problem that is solved by mixed-integer hybrid differential evolution in order to obtain a global design. The double-stage process can use a smaller amount of fresh solvent to increase ethanol productivity compared with that of the single-stage process, but it will also decrease overall conversion. Comparing the case studies, the simultaneous process/solvent design could yield higher overall ethanol productivity than that of the process design. The maximum ethanol production rate for the double-stage extractive fermentation with cell recycling was about 10-fold higher than that of continuous fermentation and about twofold higher than that of continuous fermentation with cell recycling. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：258 / 265

页数：8

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