Efficacy of Tigecycline Alone and in Combination with Gentamicin in the Treatment of Experimental Endocarditis Due to Linezolid-Resistant Enterococcus faecium

被引：11
|
作者：
Pontikis, Konstantinos [1 ]
Pefanis, Angelos [2 ]
Tsaganos, Thomas [1 ]
Tzepi, Ira-Maria [1 ]
Carrer, Dionyssia-Pinelopi [1 ]
Giamarellou, Helen [1 ]
机构：
[1] Univ Athens, Attikon Gen Hosp, Dept Internal Med 4, Athens, Greece
[2] Sotiria Chest Dis & Gen Hosp Athens, Dept Internal Med, Athens, Greece
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2013年 / 57卷 / 07期
关键词：
PHARMACODYNAMICS; PHARMACOKINETICS; DAPTOMYCIN; GAR-936;
D O I：
10.1128/AAC.00646-13
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
We evaluated the efficacy of tigecycline in a rabbit model of experimental endocarditis caused by a linezolid-resistant clinical strain of Enterococcus faecium. Tigecycline-treated animals had a 2.8- log7(10)-CFU/g reduction in microbial counts in excised vegetations compared with controls. Addition of gentamicin caused a further arithmetical reduction in colony counts. The therapeutic effect was sustained 5 days after completion of treatment, as shown by relapse studies performed in treatment groups.
引用
收藏
页码：3392 / 3394
页数：3
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