GLOMERULAR DISEASES Podocyte hypertrophy mismatch and glomerular disease

被引：30

作者：

Kriz, Wilhelm ^{[1
]}

机构：

[1] Univ Heidelberg, Med Fac Mannheim, Dept Anat & Dev Biol, D-68167 Mannheim, Germany

来源：

NATURE REVIEWS NEPHROLOGY | 2012年 / 8卷 / 11期

关键词：

GLOMERULOSCLEROSIS; PROGRESSION; EXCRETION; RATS;

D O I：

10.1038/nrneph.2012.198

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Cell hypertrophy is the only mechanism by which podocytes can cope with increased functional demands, whereas other glomerular cells can adapt by cell proliferation. In the setting of systemically stimulated glomerular growth, a 'mismatch' of inadequate podocyte hypertrophy and overall glomerular growth may lead to podocyte loss and development of focal segmental glomerulosclerosis.

引用

页码：618 / 619

页数：3

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