Cord-Blood Lipidome in Progression to Islet Autoimmunity and Type 1 Diabetes

被引:24
|
作者
Lamichhane, Santosh [1 ,2 ]
Ahonen, Linda [3 ]
Dyrlund, Thomas Sparholt [3 ]
Dickens, Alex M. [1 ,2 ]
Siljander, Heli [4 ,5 ]
Hyoty, Heikki [6 ,7 ]
Ilonen, Jorma [8 ,9 ]
Toppari, Jorma [10 ,11 ]
Veijola, Riitta [12 ,13 ,14 ]
Hyotylainen, Tuulia [15 ]
Knip, Mikael [4 ,5 ,16 ,17 ]
Oresic, Matej [1 ,2 ,18 ]
机构
[1] Univ Turku, Turku Ctr Biotechnol, FIN-20520 Turku, Finland
[2] Abo Akad Univ, FIN-20520 Turku, Finland
[3] Steno Diabet Ctr Copenhagen, DK-2820 Gentofte, Denmark
[4] Univ Helsinki, Helsinki Univ Hosp, Childrens Hosp, FIN-00290 Helsinki, Finland
[5] Univ Helsinki, Res Program Unit, Diabet & Obes, FIN-00290 Helsinki, Finland
[6] Univ Tampere, Fac Med & Life Sci, Tampere 33014, Finland
[7] Pirkanmaa Hosp Dist, Fimlab Labs, Tampere 33014, Finland
[8] Univ Turku, Inst Biomed, Immunogenet Lab, FIN-20520 Turku, Finland
[9] Turku Univ Hosp, Clin Microbiol, Turku 20014, Finland
[10] Univ Turku, Ctr Integrat Physiol & Pharmacol, Inst Biomed, Turku 20014, Finland
[11] Turku Univ Hosp, Dept Pediat, Turku 20521, Finland
[12] Univ Oulu, Med Res Ctr, Dept Pediat, PEDEGO Res Unit, Oulu 90014, Finland
[13] Oulu Univ Hosp, Dept Children & Adolescents, Oulu 90220, Finland
[14] Karolinska Inst, Dept Womens & Childrens Hlth, S-17177 Stockholm, Sweden
[15] Orebro Univ, Sch Sci & Technol, S-70281 Orebro, Sweden
[16] Tampere Univ Hosp, Tampere Ctr Child Hlth Res, Tampere 33520, Finland
[17] Folkhalsan Res Ctr, Helsinki 00290, Finland
[18] Orebro Univ, Sch Med Sci, S-70281 Orebro, Sweden
来源
BIOMOLECULES | 2019年 / 9卷 / 01期
基金
芬兰科学院;
关键词
type; 1; diabetes; cord blood; lipidomics; metabolomics; autoimmunity; METABOLISM; PHOSPHATIDYLCHOLINE; DISCOVERY;
D O I
10.3390/biom9010033
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Previous studies suggest that children who progress to type 1 diabetes (T1D) later in life already have an altered serum lipid molecular profile at birth. Here, we compared cord blood lipidome across the three study groups: children who progressed to T1D (PT1D; n = 30), children who developed at least one islet autoantibody but did not progress to T1D during the follow-up (P1Ab; n = 33), and their age-matched controls (CTR; n = 38). We found that phospholipids, specifically sphingomyelins, were lower in T1D progressors when compared to P1Ab and the CTR. Cholesterol esters remained higher in PT1D when compared to other groups. A signature comprising five lipids was predictive of the risk of progression to T1D, with an area under the receiver operating characteristic curve (AUROC) of 0.83. Our findings provide further evidence that the lipidomic profiles of newborn infants who progress to T1D later in life are different from lipidomic profiles in P1Ab and CTR.
引用
收藏
页数:9
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