A triazene-based new photolabile linker in solid phase chemistry

被引：28
|
作者：
Enders, D
Rijksen, C
Bremus-Köbberling, E
Gillner, A
Köbberling, J
机构：
[1] Rhein Westfal TH Aachen, Inst Organ Chem, D-42074 Aachen, Germany
[2] Fraunhofer Inst Lasertech, D-52074 Aachen, Germany
[3] Bayer Healthcare, Pharma Res, D-42096 Wuppertal, Germany
来源：
TETRAHEDRON LETTERS | 2004年 / 45卷 / 13期
关键词：
solid phase synthesis; photochemistry; cleavage; triazene; amino acid;
D O I：
10.1016/j.tetlet.2004.02.002
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An extension of the T2 linker methodology by showing its applicability as a photocleavable linker is reported. Photocleavage was carried out with 355 nm UV laser irradiation (3omega Nd-YAG) in methanol/diethyl ether and is suitable for protected amino acid derivatives, as well as simple small organic molecules including resin-bound biotin. The linker is stable under a wide range of conditions with the exception of strongly acidic media. (C) 2004 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2839 / 2841
页数：3
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