Sesquiterpene lactones from Ferula oopoda and their cytotoxic properties

被引：26
|
作者：
Kasaian, Jamal [1 ,3 ,4 ]
Iranshahy, Milad [1 ,3 ,4 ]
Masullo, Milena [2 ,5 ]
Piacente, Sonia [2 ,5 ]
Ebrahimi, Fatemeh [1 ,3 ,4 ]
Iranshahi, Mehrdad [1 ,3 ,4 ]
机构：
[1] Mashhad Univ Med Sci, Biotechnol Res Ctr & Sch Pharm, Mashhad, Iran
[2] Univ Studi Salerno, Dipartimento Scienze Farmaceutiche, Salerno, Italy
[3] Mashhad Univ Med Sci, Biotechnol Res Ctr, Mashhad, Iran
[4] Mashhad Univ Med Sci, Sch Pharm, Mashhad, Iran
[5] Univ Salerno, Dipartimento Sci Farmaceut, I-84084 Salerno, Italy
来源：
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2014年 / 16卷 / 03期
基金：
美国国家科学基金会;
关键词：
Ferula; Apiaceae; cytotoxic; Alamar blue; dehydrooopodin; sesquiterpene lactones; COUMARINS;
D O I：
10.1080/10286020.2013.866099
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Two new sesquiterpene lactones, namely feruhodin A (1) and feruhodin B (2), together with six known compounds, daucoeudesmanolactone (4), dehydrooopodin (5), oopodin (6), badkhysin (3), 7-demethylplastochromenol (7), and scoparone (8), were isolated from the roots of Ferula oopoda. The structures of these compounds were elucidated by 1D and 2D NMR techniques as well as high-resolution mass spectrometry. Cytotoxic effects of these compounds were evaluated against two human cancer cell lines including MCF7and K562 using the Alamar blue assay. The results showed that dehydrooopodin (5) possessed significant cytotoxic effects with IC50 values of 15 and 5M against MCF7 and K562, respectively.
引用
收藏
页码：248 / 253
页数：6
相关论文
共 50 条
  • [31] Cytotoxic sesquiterpene lactones from Centaurothamnus maximus and Vicoa pentanema
    Muhammad, W
    Takamatsu, S
    Mossa, JS
    El-Feraly, FS
    Walker, LA
    Clark, AM
    PHYTOTHERAPY RESEARCH, 2003, 17 (02) : 168 - 173
  • [32] Cytotoxic sesquiterpene lactones from Campuloclinium macrocephalum (=Eupatorium macrocephalum)
    Pereira Cabral, Marcia R.
    Cecchetto, Mariana
    Batista, Joao M., Jr.
    Batista, Andrea N. L.
    Foglio, Mary Ann
    Tasca Gois Ruiz, Ana Lucia
    Barrotto do Carmo, Marta R.
    da Costa, Willian Ferreira
    Baldoqui, Debora C.
    Sarragiotto, Maria H.
    PHYTOCHEMISTRY, 2020, 179
  • [33] Cytotoxic sesquiterpene lactones from Vernonia pachyclada from the Madagascar rainforest
    Williams, RB
    Norris, A
    Slebodnick, C
    Merola, J
    Miller, JS
    Andriantsiferana, R
    Rasamison, VE
    Kingston, DGI
    JOURNAL OF NATURAL PRODUCTS, 2005, 68 (09): : 1371 - 1374
  • [34] Sesquiterpene coumarins with anti-vitiligo and cytotoxic activities from Ferula samarkandica
    Zhang, Miao-Miao
    Kamoldinov, Khamidulla
    Nueraihemaiti, Mayire
    Turdu, Gulmira
    Zou, Guo-An
    Aisa, Haji Akber
    PHYTOCHEMISTRY LETTERS, 2024, 61 : 21 - 28
  • [35] STEREOCHEMISTRY OF GUAIANOLIDES FERULA-OOPODA
    SERKEROV, SV
    KHIMIYA PRIRODNYKH SOEDINENII, 1980, (05): : 629 - 633
  • [36] Cytotoxic sesquiterpene lactones of Egyptian Tanacetum santolinoides
    Youssef, Diaa T. A.
    Ramadan, Mahmoud A.
    Ibrahim, Sabrin R. M.
    Badr, Jihan M.
    NATURAL PRODUCT COMMUNICATIONS, 2007, 2 (08) : 795 - 798
  • [37] NEW SESQUITERPENIC LACTONE BADGHYSIN FROM RESIN OF FERULA OOPODA BOISS
    KIRYALOV, NP
    SERKEROV, SV
    JOURNAL OF GENERAL CHEMISTRY USSR, 1964, 34 (08): : 2843 - &
  • [38] Cytotoxic effects of sesquiterpene lactones from the flowers of Hemisteptia lyrata B
    Ha, TJ
    Jang, DS
    Lee, JR
    Lee, KD
    Lee, J
    Hwang, SW
    Jung, HJ
    Nam, SH
    Park, KH
    Yang, MS
    ARCHIVES OF PHARMACAL RESEARCH, 2003, 26 (11) : 925 - 928
  • [39] NEW GUANOLIDE - OPOFERSIN FROM FERULA-OOPODA ROOTS
    SERKEROV, SV
    RIKHLEVSKA, U
    ALESKEROVA, AN
    MIRBABAEV, NF
    KHIMIYA PRIRODNYKH SOEDINENII, 1991, (03): : 318 - 319
  • [40] Cytotoxic sesquiterpene Lactones from Eupatorium kiirunense, a coastal plant of Taiwan
    Shen, YC
    Lo, KL
    Kuo, YH
    Khalil, AT
    JOURNAL OF NATURAL PRODUCTS, 2005, 68 (05): : 745 - 750
12345