Antimicrobial Activity and Urease Inhibition of Schiff Bases Derived from Isoniazid and Fluorinated Benzaldehydes and of Their Copper(II) Complexes

被引：32
|
作者：
Habala, Ladislav [1 ]
Varenyi, Samuel [1 ]
Bilkova, Andrea [2 ]
Herich, Peter [1 ,3 ]
Valentova, Jindra [1 ]
Kozisek, Jozef [3 ]
Devinsky, Ferdinand [1 ]
机构：
[1] Comenius Univ, Fac Pharm, Dept Chem Theory Drugs, Kalinciakova 8, SK-83232 Bratislava, Slovakia
[2] Comenius Univ, Fac Pharm, Dept Cellular & Mol Biol Drugs, Kalinciakova 8, SK-83232 Bratislava, Slovakia
[3] Slovak Univ Technol Bratislava, Fac Chem & Food Technol, Dept Phys Chem, Radlinskeho 9, SK-81237 Bratislava, Slovakia
来源：
MOLECULES | 2016年 / 21卷 / 12期
关键词：
copper(II) complexes; urease inhibitors; antimicrobial activity; fluorine; isoniazid; N-BENZIMIDAZOLYLMETHYLETHYLENEDIAMINEDIACETIC ACID; IN-VITRO ACTIVITY; CRYSTAL-STRUCTURE; METAL-COMPLEXES; COBALT(II); AGENTS;
D O I：
10.3390/molecules21121742
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In order to evaluate the influence of substitution on biological properties of Schiff bases and their metal complexes, a series of differently substituted fluorine-containing Schiff bases starting from the drug isoniazid (isonicotinylhydrazide) were prepared and their structures were established by single-crystal X-ray diffraction. Also, four copper(II) complexes of these Schiff bases were synthesized. The prepared compounds were evaluated for their antimicrobial activity and urease inhibition. Two of the Schiff bases exerted activity against C. albicans. All copper(II) complexes showed excellent inhibitory properties against jack bean urease, considerably better than that of the standard inhibitor acetohydroxamic acid.
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页数：14
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