MLN8054 selectively inhibits Aurora A over Aurora B in cultured human tumor cells.

被引：0
|
作者：
Hoar, KM [1 ]
Wysong, DR [1 ]
Ecsedy, JA [1 ]
机构：
[1] Millennium Pharmaceut Inc, Cambridge, MA USA
来源：
CLINICAL CANCER RESEARCH | 2005年 / 11卷 / 24期
关键词：
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
引用
收藏
页码：9109S / 9109S
页数：1
相关论文
共 50 条
  • [21] MLN8054, A SMALL MOLECULE INHIBITOR OF AURORA KINASE A, SENSITIZES ANDROGEN-RESISTANT PROSTATE CANCER TO RADIATION
    Moretti, Luigi
    Niermann, Kenneth
    Schleicher, Stephen
    Giacalone, Nicholas J.
    Varki, Vinod
    Kim, Kwang Woon
    Kopsombut, Prapaporn
    Jung, Dae Kwang
    Lu, Bo
    INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2011, 80 (04): : 1189 - 1197
  • [22] Phase I assessment of mechanistic pharmacodynamic biomarkers for MLN8054, a small-molecule inhibitor of Aurora A kinase
    Chakravarty, A.
    Shinde, V. B.
    Galvin, K.
    Silverman, L.
    Stringer, B.
    Danaee, H.
    Eton, O.
    Manfredi, M.
    EJC SUPPLEMENTS, 2008, 6 (12): : 32 - 32
  • [23] MLN8054, A NOVEL INHIBITOR OF AURORA KINASE A SENSITIZES ANDROGEN-RESISTANT PROSTATE CANCER MODELS TO RADIATION
    Moretti, L.
    Niermann, K.
    Schleicher, S.
    Kim, K. W.
    Kopsombut, P.
    Jung, D. K.
    Lu, B.
    RADIOTHERAPY AND ONCOLOGY, 2011, 99 : S386 - S386
  • [24] Drug-Resistant Aurora A Mutants for Cellular Target Validation of the Small Molecule Kinase Inhibitors MLN8054 and MLN8237
    Sloane, Dominic A.
    Trikic, Michael Z.
    Chu, Matthew L. H.
    Lamers, Maria B. A. C.
    Mason, Clive S.
    Mueller, Ilka
    Savory, Wendy J.
    Williams, David H.
    Eyers, Patrick A.
    ACS CHEMICAL BIOLOGY, 2010, 5 (06) : 563 - 576
  • [25] MLN8054, a small-molecule inhibitor of Aurora A, causes spindle pole and chromosome congression defects leading to aneuploidy
    Hoar, Kara
    Chakravarty, Arijit
    Rabino, Claudia
    Wysong, Deborah
    Bowman, Douglas
    Roy, Natalie
    Ecsedy, Jeffrey A.
    MOLECULAR AND CELLULAR BIOLOGY, 2007, 27 (12) : 4513 - 4525
  • [26] Phase I Study of the Selective Aurora A Kinase Inhibitor MLN8054 in Patients with Advanced Solid Tumors: Safety, Pharmacokinetics, and Pharmacodynamics
    Macarulla, Teresa
    Cervantes, Andres
    Elez, Elena
    Rodriguez-Braun, Edith
    Baselga, Jose
    Rosello, Susana
    Sala, Gemma
    Blasco, Inma
    Danaee, Hadi
    Lee, Yih
    Ecsedy, Jeffrey
    Shinde, Vaishali
    Chakravarty, Arijit
    Bowman, Douglas
    Liu, Hua
    Eton, Omar
    Fingert, Howard
    Tabernero, Josep
    MOLECULAR CANCER THERAPEUTICS, 2010, 9 (10) : 2844 - 2852
  • [27] Phase I Assessment of New Mechanism-Based Pharmacodynamic Biomarkers for MLN8054, a Small-Molecule Inhibitor of Aurora A Kinase
    Chakravarty, Arijit
    Shinde, Vaishali
    Tabernero, Josep
    Cervantes, Andres
    Cohen, Roger B.
    Dees, E. Claire
    Burris, Howard
    Infante, Jeffrey R.
    Macarulla, Teresa
    Elez, Elena
    Andreu, Jordi
    Rodriguez-Braun, Edith
    Rosello, Susana
    von Mehren, Margaret
    Meropol, Neal J.
    Langer, Corey J.
    ONeil, Bert
    Bowman, Douglas
    Zhang, Mengkun
    Danaee, Hadi
    Faron-Yowe, Laura
    Gray, Gary
    Liu, Hua
    Pappas, Jodi
    Silverman, Lee
    Simpson, Chris
    Stringer, Bradley
    Tirrell, Stephen
    Veiby, Ole Petter
    Venkatakrishnan, Karthik
    Galvin, Katherine
    Manfredi, Mark
    Ecsedy, Jeffrey A.
    CANCER RESEARCH, 2011, 71 (03) : 675 - 685
  • [28] VX-680 inhibits Aurora A and Aurora B kinase activity in human cells
    Tyler, Rebecca K.
    Shpiro, Natalia
    Marquez, Rodolfo
    Eyers, Patrick A.
    CELL CYCLE, 2007, 6 (22) : 2846 - 2854
  • [29] Broad-based anti-tumor activity of the Aurora A kinase inhibitor, MLN8054.
    Zhang, MK
    Burenkova, O
    Chandra, S
    Connolly, K
    Huck, J
    Manfredi, MG
    Saylor, M
    Zhang, YM
    Meetze, KA
    CLINICAL CANCER RESEARCH, 2005, 11 (24) : 9082S - 9082S
  • [30] Molecular dynamics and free energy studies on Aurora kinase A and its mutant bound with MLN8054: insight into molecular mechanism of subtype selectivity
    Yang, Ying
    Shen, Yulin
    Li, Shuyan
    Jin, Nengzhi
    Liu, Huanxiang
    Yao, Xiaojun
    MOLECULAR BIOSYSTEMS, 2012, 8 (11) : 3049 - 3060
12345