MicroRNA-146a modulates human bronchial epithelial cell survival in response to the cytokine-induced apoptosis

被引：65

作者：

Liu, Xiangde ^{[1
]}

Nelson, Amy ^{[1
]}

Wang, Xingqi ^{[1
]}

Kanaji, Nobuhiro ^{[1
]}

Kim, Miok ^{[1
]}

Sato, Tadashi ^{[1
]}

Nalanishi, Masanori ^{[1
]}

Li, YingJi ^{[1
]}

Sun, Jianhong ^{[1
]}

Michalski, Joel ^{[1
]}

Patil, Amol ^{[1
]}

Basma, Hesham ^{[1
]}

Rennard, Stephen I. ^{[1
]}

机构：

[1] Univ Nebraska Med Ctr, Dept Internal Med, Omaha, NE 68198 USA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2009年 / 380卷 / 01期

关键词：

miRNA; Bronchial epithelial cell; Survival; Apoptosis; CANCER-CELLS; THERAPEUTIC IMPLICATIONS; RHEUMATOID-ARTHRITIS; REDUCED EXPRESSION; SIGNALING PATHWAY; SYNOVIAL TISSUE; INFLAMMATION; LUNG; ASTHMA; INTERLEUKIN-1-BETA;

D O I：

10.1016/j.bbrc.2009.01.066

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

MicroRNA plays an important role in cell differentiation, proliferation and cell death. The current study found that miRNA-146a was up-regulated in human bronchial epithelial cells (HBECs) in response to stimulation by TGF-beta 1 Plus cytomix (a mixture of IL-1 beta, IFN-gamma and TNF-alpha). TGF-beta 1 plus cytomix (TCM) induced apoptosis in HBECs (3.4 +/- 0.6% of control vs 83.1 +/- 4.0% of TCM treated cells, p < 0.01), and this was significantly blocked by the miRNA-146a mimic (8.8 +/- 1.5%, p < 0.01). In contrast, a miRNA-146a, inhibitor had only a modest effect on cell survival but appeared to augment the induction of epithelial-mesenchymal transition (EMT) in response to the cytokines. The MicroRNA-146a mimic appears to modulate HBEC survival through a mechanism of up-regulating Bcl-XL and STAT3 phosphorylation, and by this mechanism it could contribute to tissue repair and remodeling. (C) 2009 Elsevier Inc. All rights reserved

引用

页码：177 / 182

页数：6

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