Identification of genes responsive to apoptosis in HL-60 cells

被引：0
|
作者：
Jin, W
Qu, LF
Min, P
Chen, S
Hong, L
Lu, H
Hou, YT [1 ]
机构：
[1] Chianghai Hosp, Dept Vasc Surg, Shanghai 200433, Peoples R China
[2] Chianghai Hosp, Inst Vasc Surg PLA, Shanghai 200433, Peoples R China
[3] Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
[4] Ruijin Hosp, Le Pole Franco Chinois Sci Vivant & Genom, Shanghai 200025, Peoples R China
来源：
ACTA PHARMACOLOGICA SINICA | 2004年 / 25卷 / 03期
关键词：
HL-60; cells; homoharringtonine; apoptosis; oligonucleotide array sequence analysis; gene expression;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
AIM: To identify genes responsive to apoptosis in HL-60 cells treated by homoharringtonine. METHODS: cDNA microarray technology was used to detect gene expression and the result of microarrays for genes (TIEG and VDUP1) was confirmed by Northern analysis. RESULTS: Seventy-five individual mRNAs whose mass changed significantly were identified. Among these genes (25 were up-regulated and 50 were down-regulated), most are known related to oncogenes and tumor suppressor. Some genes were involved in apoptosis signaling pathways. CONCLUSION: TGFbeta and TNF apoptosis signaling pathways were initiated during apoptosis in HL-60 cells. TIEG and VDUP1 play important roles in mediating apoptosis.
引用
收藏
页码：319 / 326
页数：8
相关论文
共 50 条
  • [41] Regulation of Histone Acetylation and Apoptosis by Trichostatin in HL-60 Cells
    李新刚
    陈维凯
    谷俊侠
    崔国惠
    陈燕
    华中科技大学学报(医学英德文版), 2004, (06) : 572 - 574
  • [42] Induction of apoptosis by rosemary polyphenols in HL-60 cells.
    Lin-Shiau, SY
    Lo, AH
    Ho, CT
    Lin, JK
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2002, 223 : U45 - U45
  • [43] Effect of phosphodiesterases in the regulation of apoptosis in HL-60 cells.
    Zhu, WH
    MajlufCruz, A
    Omburo, G
    FASEB JOURNAL, 1997, 11 (03): : 662 - 662
  • [44] APOPTOSIS MODELS IN HL-60 AND L929 CELLS
    BARBIERO, G
    DURANTI, F
    GOGLIO, G
    DICANTOGNO, LV
    MARTINIS, O
    SACCHI, C
    AUTELLI, R
    SARGUS, MJ
    AMENTA, JS
    BACCINO, FM
    BONELLI, G
    FUNDAMENTAL AND CLINICAL IMMUNOLOGY, 1995, 3 (02): : 88 - 89
  • [45] Role of calcium in apoptosis of HL-60 cells induced by harringtonine
    Min Fang
    Hongqing Zhang
    Shaobai Xue
    Science in China Series C: Life Sciences, 1998, 41 : 600 - 607
  • [46] Anaplasma phagocytophilum infection induces apoptosis in HL-60 cells
    Pratap Karki
    Jacob W. IJdo
    World Journal of Microbiology and Biotechnology, 2011, 27 : 2741 - 2746
  • [47] Role of calcium in apoptosis of HL-60 cells induced by harringtonine
    方敏
    张鸿卿
    薛绍白
    Science in China(Series C:Life Sciences), 1998, (06) : 600 - 607
  • [48] Induction of apoptosis in HL-60 cells treated with medicinal herbs
    Nishida, S
    Kikuichi, S
    Yoshioka, S
    Tsubaki, M
    Fujii, Y
    Matsuda, H
    Kubo, M
    Irimajiri, K
    AMERICAN JOURNAL OF CHINESE MEDICINE, 2003, 31 (04): : 551 - 562
  • [49] Sonodynamically induced apoptosis with porfimer sodium in HL-60 cells
    Yumita, Nagahiko
    Han, Oing-Song
    Umemura, Shin-Ichiro
    ANTI-CANCER DRUGS, 2007, 18 (10) : 1149 - 1156
  • [50] An efficient strategy to identify early TPA-responsive genes during differentiation of HL-60 cells
    Hu, Ling-Yueh
    Tepper, Clifford G.
    Lo, Su-Hao
    Lin, Wen-Chang
    GENE EXPRESSION, 2006, 13 (03): : 179 - 189
12345