Identification of genes responsive to apoptosis in HL-60 cells

被引：0
|
作者：
Jin, W
Qu, LF
Min, P
Chen, S
Hong, L
Lu, H
Hou, YT [1 ]
机构：
[1] Chianghai Hosp, Dept Vasc Surg, Shanghai 200433, Peoples R China
[2] Chianghai Hosp, Inst Vasc Surg PLA, Shanghai 200433, Peoples R China
[3] Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
[4] Ruijin Hosp, Le Pole Franco Chinois Sci Vivant & Genom, Shanghai 200025, Peoples R China
来源：
ACTA PHARMACOLOGICA SINICA | 2004年 / 25卷 / 03期
关键词：
HL-60; cells; homoharringtonine; apoptosis; oligonucleotide array sequence analysis; gene expression;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
AIM: To identify genes responsive to apoptosis in HL-60 cells treated by homoharringtonine. METHODS: cDNA microarray technology was used to detect gene expression and the result of microarrays for genes (TIEG and VDUP1) was confirmed by Northern analysis. RESULTS: Seventy-five individual mRNAs whose mass changed significantly were identified. Among these genes (25 were up-regulated and 50 were down-regulated), most are known related to oncogenes and tumor suppressor. Some genes were involved in apoptosis signaling pathways. CONCLUSION: TGFbeta and TNF apoptosis signaling pathways were initiated during apoptosis in HL-60 cells. TIEG and VDUP1 play important roles in mediating apoptosis.
引用
收藏
页码：319 / 326
页数：8
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