Multi-ancestral meta-analysis yields novel genetic loci for asthma exacerbations

被引：0

作者：

Herrera Luis, E. ^{[1
]}

Ortega, V. E. ^{[2
]}

Ampleford, E. J. ^{[3
]}

Sio, Y. Y. ^{[4
]}

Granell, R. ^{[5
]}

De Roos, E. ^{[6
,7
]}

Terzikhan, N. ^{[6
,7
]}

Vergara, E. Elorduy ^{[8
]}

Hernandez-Pacheco, N. ^{[9
,10
]}

Perez-Garcia, J. ^{[1
]}

Martin-Gonzalez, E. ^{[1
]}

Lorenzo-Diaz, F. ^{[1
,11
]}

Hashimoto, S. ^{[12
]}

Brinkman, P. ^{[12
]}

Jorgensen, A. L. ^{[13
]}

Yan, Q. ^{[14
]}

Forno, E. ^{[15
]}

Vijverberg, S. J. ^{[16
,17
,18
]}

Lethem, R. ^{[5
]}

Espuela-Ortiz, A. ^{[1
]}

Gorenjak, M. ^{[19
]}

Eng, C. ^{[20
]}

Gonzalez-Perez, R. ^{[21
]}

Hernandez-Perez, J. M. ^{[22
,23
,24
]}

Poza-Guedes, P. ^{[21
]}

Sardon, O. ^{[25
,26
]}

Corcuera, P. ^{[26
]}

Hawkins, G. A. ^{[27
]}

Marsico, A. ^{[28
]}

Bahmer, T. ^{[29
,30
]}

Rabe, K. F. ^{[29
,30
]}

Hansen, G. ^{[31
]}

Kopp, M., V ^{[32
,33
,34
]}

Rios, R. ^{[35
]}

Cruz, M. J. ^{[9
,36
]}

Gonzalez-Barcala, F. ^{[37
]}

Olaguibel, J. M. ^{[9
,38
]}

Plaza, V ^{[9
,39
]}

Quirce, S. ^{[9
,40
]}

Canino, G. ^{[41
]}

Cloutier, M. ^{[42
]}

Del Pozo, V ^{[9
,43
]}

Rodriguez-Santana, J. R. ^{[44
]}

Korta-Murua, J. ^{[25
]}

Villar, J. ^{[9
,45
]}

Potocnik, U. ^{[19
]}

Figueiredo, C. ^{[46
]}

Kabesch, M. ^{[47
]}

Mukhopadhyay, S. ^{[48
,49
]}

Pirmohamed, M. ^{[50
]}

机构：

[1] Univ La Laguna ULL, Dept Biochem Microbiol Cell Biol & Genet, Genom & Hlth Grp, San Cristobal la Laguna, Spain

[2] Mayo Clin, Div Resp Med, Dept Internal Med, Scottsdale, AZ USA

[3] Wake Forest Sch Med, Ctr Precis Med, Dept Internal Med, Winston Salem, NC USA

[4] Natl Univ Singapore, Dept Biol Sci, Singapore, Singapore

[5] Univ Bristol, Bristol Med Sch, Populat Hlth Sci, MRC Integrat Epidemiol Unit IEU, Oakfield Grove, England

[6] Ghent Univ Hosp, Dept Resp Med, Ghent, Belgium

[7] Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands

[8] German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Inst Computat Biol, Munich, Germany

[9] CIBER Enfermedades Resp CIBERES, Madrid, Spain

[10] Karolinska Inst, Sodersjukhuset, Dept Clin Sci & Educ, Stockholm, Sweden

[11] Univ La Laguna ULL, Inst Univ Enfermedades Trop & Salud PUbl Canarias, San Cristobal la Laguna, Spain

[12] Univ Amsterdam, Amsterdam Univ Med Ctr, Dept Resp Med, Amsterdam, Netherlands

[13] Univ Liverpool, Inst Populat Hlth, Dept Hlth Data Sci, Liverpool, Merseyside, England

[14] Columbia Univ, Dept Obstet & Gynecol, Irving Med Ctr, New York, NY USA

[15] Univ Pittsburgh, UPMC Childrens Hosp Pittsburgh, Div Pediat Pulm Med, Pittsburgh, PA USA

[16] Univ Utrecht, Fac Sci, Div Pharmacoepidemiol & Clin Pharmacol, Utrecht, Netherlands

[17] Univ Amsterdam, Emmas Children Hosp, Amsterdam UMC, Dept Paediat Resp Med & Allergy, Amsterdam, Netherlands

[18] Univ Amsterdam, Dept Resp Med, Amsterdam UMC, Amsterdam, Netherlands

[19] Univ Maribor, Fac Med, Ctr Human Mol Genet & Pharmacogen, Maribor, Slovenia

[20] Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA

[21] Hosp Univ Canarias, Allergy Dept, Severe Asthma Unit, Santa Cruz De Tenerife, Spain

[22] Hosp Univ Canarias, Allergy Dept, Santa Cruz De Tenerife, Spain

[23] Hosp Gen La Palma, Pulm Med, La Palma, Santa Cruz De T, Spain

[24] Hosp Univ NS Candelaria, Pulm Med, Santa Cruz De Tenerife, Spain

[25] Univ Basque Country UPV EHU, Dept Pediat, San Sebastian, Spain

[26] Hosp Univ Donostia, Div Pediat Resp Med, San Sebastian, Spain

[27] Wake Forest Sch Med, Dept Biochem, Winston Salem, NC USA

[28] German Res Ctr Environm Hlth, Computat Hlth Ctr, Helmholtz Zentrum Munchen, Munich, Germany

[29] LungenClin Grosshansdorf, Grosshansdorf, Germany

[30] Univ Kiel, Dept Med, Kiel, Germany

[31] Hannover Med Sch, Dept Pediat Pneumol Allergol & Neonatol, Hannover, Germany

[32] German Ctr Lung Res DZL, Airway Res Ctr North ARCN, Bern, Switzerland

[33] Univ Bern, Univ Childrens Hosp Bern, Inselspital, Dept Paediat Resp Med, Bern, Switzerland

[34] Univ Med Ctr Schleswig Holstein, Div Pediat Pneumol & Allergol, Lubeck, Germany

[35] Univ Fed Bahia UFBA, Inst Ciencias Saude, Programa Posgrad Imunol PPGIm, Salvador, BA, Brazil

[36] Hosp Valle De Hebron, Serv Neumol, Barcelona, Spain

[37] Complejo Hosp Univ Santiago, Serv Neumol, Santiago De Compostela, Spain

[38] Complejo Hosp Navarra, Serv Alergol, Pamplona, Spain

[39] Hosp Santa Creu & Sant Pau, Inst Invest Biomed St Pau IIB St Pau, Dept Med Resp, Barcelona, Spain

[40] La Paz Univ Hosp, IdiPAZ, Dept Allergy, Madrid, Spain

[41] Univ Puerto Rico, Behav Sci Res Inst, San Juan, PR 00936 USA

[42] Univ Connecticut, Dept Pediat, Farmington, CT USA

[43] Inst Invest Sanitaria Hosp Univ Fdn Jimenez Diaz, Immunol Dept, Madrid, Spain

[44] Ctr Neumol Pediat, San Juan, PR USA

[45] Hosp Univ Dr Negrin, Res Unit, Multidisciplinary Organ Dysfunct Evaluat Res Netw, Las Palmas Gran Canaria, Spain

[46] Univ Fed Bahia, Inst Ciencias Saude, Salvador, BA, Brazil

[47] Univ Childrens Hosp Regensburg KUNO, Dept Paediat Pneumol & Allergy, Regensburg, Germany

[48] Univ Dundee, Ninewells Hosp & Med Sch, Biomed Res Inst, Populat Pharmacogenet Grp, Dundee, Scotland

[49] Royal Alexandra Childrens Hosp, Acad Dept Paediat, Brighton & Sussex Med Sch, Brighton, E Sussex, England

[50] Univ Liverpool, Inst Syst Mol & Integrat Biol, Dept Pharmacol & Therapeut, Liverpool, Merseyside, England

来源：

EUROPEAN RESPIRATORY JOURNAL | 2022年 / 60卷

关键词：

Asthma; -; mechanism; Genetics; Genomics;

D O I：

10.1183/13993003.congress-2022.685

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

685

引用

页数：5

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