Effects of Luteolin and Quercetin in Combination with Some Conventional Antibiotics against Methicillin-Resistant Staphylococcus aureus

被引：55

作者：

Amin, Muhammad Usman ^{[1
,7
]}

Khurram, Muhammad ^{[2
]}

Khan, Taj Ali ^{[1
]}

Faidah, Hani S. ^{[3
]}

Shah, Zia Ullah ^{[4
]}

Rahman, Shafiq Ur ^{[2
]}

Haseeb, Abdul ^{[5
]}

Ilyas, Muhammad ^{[4
]}

Ullah, Naseem ^{[6
]}

Khayam, Sahibzada Muhammad Umar ^{[6
]}

Iriti, Marcello ^{[8
]}

机构：

[1] Kohat Univ Sci & Technol, Dept Microbiol, Kohat 26000, Pakistan

[2] Shaheed Benazir Bhutto Univ, Dept Pharm, Sheringal 18000, Pakistan

[3] Umm Al Qura Univ, Dept Microbiol, Fac Med, Mecca 21955, Saudi Arabia

[4] Sarhad Univ Sci & Informat Technol, Dept Microbiol Biotechnol, Peshawar 25000, Pakistan

[5] Umm Al Qura Univ, Dept Clin Pharm, Coll Pharm, Mecca 21955, Saudi Arabia

[6] Sarhad Univ Sci & Informat Technol, Dept Pharm, Peshawar 25000, Pakistan

[7] Khyber Med Univ, Dept Pharmacol, Inst Med Sci, Kohat 26000, Pakistan

[8] Milan State Univ, Dept Agr & Environm Sci, I-20133 Milan, Italy

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2016年 / 17卷 / 11期

关键词：

flavonoids; antibiotic resistance; MRSA; combination therapy; synergism; phytochemicals; IN-VITRO; ANTIBACTERIAL ACTIVITIES; ANTIMICROBIAL ACTIVITY; SYNERGISTIC ACTIVITY; NATURAL FLAVONOIDS; CELL-WALL; CATECHIN; ANTIOXIDANT; STRAINS; GALLATE;

D O I：

10.3390/ijms17111947

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The present study was designed to evaluate the effects of flavonoids luteolin (L) and quercetin + luteolin (Q + L) in combination with commonly used antibacterial agents against methicillin-resistant Staphylococcus aureus (MRSA) clinical isolates and S. aureus (ATCC 43300). Minimum inhibitory concentrations (MICs) of L and Q + L, as well as the MICs of flavonoids in combination with antibiotics were determined and results showed an increased activity of flavonoids with antibiotics. The synergistic, additive, or antagonistic relationships between flavonoids (L and Q + L) and antibiotics were also evaluated, and additive and synergistic effects were observed for some antibiotic + flavonoid combinations. In addition, some combinations were also found to damage the bacterial cytoplasmic membrane, as assessed through potassium leakage assay. The effects of flavonoids and flavonoids + antibiotics on mecA gene mutations were also tested, and no functional variation was detected in the coding region.

引用

页数：16

共 50 条

[21] Vancomycin in Combination with Other Antibiotics for the Treatment of Serious Methicillin-Resistant Staphylococcus aureus Infections
Deresinski, Stan
CLINICAL INFECTIOUS DISEASES, 2009, 49 (07) : 1072 - 1079
[22] In vitro and in vivo activity of D-serine in combination with β-lactam antibiotics against methicillin-resistant Staphylococcus aureus
Wang, Qing
Lv, Yuemeng
Pang, Jing
Li, Xue
Lu, Xi
Wang, Xiukun
Hu, Xinxin
Nie, Tongying
Yang, Xinyi
Xiong, Yan Q.
Jiang, Jiandong
Li, Congran
You, Xuefu
ACTA PHARMACEUTICA SINICA B, 2019, 9 (03) : 496 - 504
[23] In vitro and in vivo activity of D-serine in combination with β-lactam antibiotics against methicillin-resistant Staphylococcus aureus
Qing Wang
Yuemeng Lv
Jing Pang
Xue Li
Xi Lu
Xiukun Wang
Xinxin Hu
Tongying Nie
Xinyi Yang
Yan Q.Xiong
Jiandong Jiang
Congran Li
Xuefu You
Acta Pharmaceutica Sinica B, 2019, 9 (03) : 496 - 504
[24] In Vitro Activities of Antibiotics and Antimicrobial Cationic Peptides Alone and in Combination against Methicillin-Resistant Staphylococcus aureus Biofilms
Mataraci, Emel
Dosler, Sibel
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2012, 56 (12) : 6366 - 6371
[25] In vitro antimicrobial activity of pannarin alone and in combination with antibiotics against methicillin-resistant Staphylococcus aureus clinical isolates
Celenza, Giuseppe
Segatore, Bernardetta
Setacci, Domenico
Bellio, Pierangelo
Brisdelli, Fabrizia
Piovano, Marisa
Garbarino, Juan A.
Nicoletti, Marcello
Perilli, Mariagrazia
Amicosante, Gianfranco
PHYTOMEDICINE, 2012, 19 (07) : 596 - 602
[26] The effects of macrolide and quinolone antibiotics in in methicillin-resistant Staphylococcus aureus biofilm growth
Dasgupta, MK
Shishido, H
Salama, S
Singh, R
Larabie, M
Micetich, RG
ADVANCES IN PERITONEAL DIALYSIS/1997, VOL 13: SELECTED PAPERS FROM THE SEVENTEENTH ANNUAL CONFERENCE ON PERITONEAL DIALYSIS, DENVER, COLORADO, FEBRUARY 1997, 1997, 13 : 214 - 217
[27] Restoring Methicillin-Resistant Staphylococcus aureus Susceptibility to β-Lactam Antibiotics
Tan, Christopher M.
Therien, Alex G.
Lu, Jun
Lee, Sang H.
Caron, Alexandre
Gill, Charles J.
Lebeau-Jacob, Christian
Benton-Perdomo, Liliana
Monteiro, Joao M.
Pereira, Pedro M.
Elsen, Nathaniel L.
Wu, Jin
Deschamps, Kathleen
Petcu, Mihai
Wong, Simon
Daigneault, Etienne
Kramer, Susanne
Liang, Lianzhu
Maxwell, Eugene
Claveau, David
Vaillancourt, John
Skorey, Kathryn
Tam, John
Wang, Hao
Meredith, Timothy C.
Sillaots, Susan
Wang-Jarantow, Lisa
Ramtohul, Yeeman
Langlois, Eric
Landry, France
Reid, John C.
Parthasarathy, Gopal
Sharma, Sujata
Baryshnikova, Anastasia
Lumb, Kevin J.
Pinho, Mariana G.
Soisson, Stephen M.
Roemer, Terry
SCIENCE TRANSLATIONAL MEDICINE, 2012, 4 (126)
[28] Bacteriological profiling of diphenylureas as a novel class of antibiotics against methicillin-resistant Staphylococcus aureus
Mohammad, Haroon
Younis, Waleed
Ezzat, Hany G.
Peters, Christine E.
AbdelKhalek, Ahmed
Cooper, Bruce
Pogliano, Kit
Pogliano, Joe
Mayhoub, Abdelrahman S.
Seleem, Mohamed N.
PLOS ONE, 2017, 12 (08):
[29] Restoring susceptibility to β-lactam antibiotics in methicillin-resistant Staphylococcus aureus
Nguyen, Van T.
Birhanu, Biruk T.
Miguel-Ruano, Vega
Kim, Choon
Batuecas, Mayte
Yang, Jingdong
El-Araby, Amr M.
Jimenez-Faraco, Eva
Schroeder, Valerie A.
Alba, Alejandra
Rana, Neha
Sader, Safaa
Thomas, Caitlyn A.
Feltzer, Rhona
Lee, Mijoon
Fisher, Jed F.
Hermoso, Juan A.
Chang, Mayland
Mobashery, Shahriar
NATURE CHEMICAL BIOLOGY, 2024, : 482 - 489
[30] Bicarbonate Resensitization of Methicillin-Resistant Staphylococcus aureus to β-Lactam Antibiotics
Ersoy, Selvi C.
Abdelhady, Wessam
Li, Liang
Chambers, Henry F.
Xiong, Yan Q.
Bayer, Arnold S.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2019, 63 (07)

← 1 2 3 4 5 →