AK-968 efficiently inhibits proliferation and induces cell apoptosis in human multiple myeloma cells

被引：0
|
作者：
Dai, Yibo [1 ,2 ]
Xu, Yaqi [1 ,2 ]
Jiang, Yang [1 ,2 ]
Jiang, Wen [1 ,2 ,3 ]
Liu, Xiaoli [1 ,2 ]
Zhang, Chengyun [1 ,2 ]
机构：
[1] Shandong Univ, Hosp 2, Hematol Dept, Jinan, Shandong, Peoples R China
[2] Shandong Univ, Inst Biotherapy Hematol Malignancies, Jinan, Shandong, Peoples R China
[3] Shandong Univ, Hosp 2, Ctr Lab, Jinan, Shandong, Peoples R China
来源：
PHARMAZIE | 2019年 / 74卷 / 03期
关键词：
THALIDOMIDE; CASPASE-3;
D O I：
10.1691/ph.2019.8914
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
AK-968 is a small molecular weight compound. In this study, we evaluated its anti-tumor effects on human multiple myeloma (MM) cells. Our results demonstrated that AK-968 markedly inhibited proliferation of MM cell lines in a dose-and time-dependent manner. Additionally, our flow cytometry data showed that MM cell apoptosis was significantly induced by AK-968. As expected, caspase-3 cleavage and alternation of mitochondrial membrane potential (MMP) in the MM cells treated by AK-968 was detected or quantified by Western Blot or Flow cytometry technique, respectively. In conclusion, our results suggested that AK-968 may act as a potential drug to treat human multiple myeloma.
引用
收藏
页码：150 / 153
页数：4
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