Recurrent multiple neurofibromatosis type 1 of the right lower limb

被引:0
|
作者
Huang, Leitao [1 ]
Wu, Xia [2 ]
Ding, Yi [1 ]
Qi, Lai [1 ]
Li, Wei [1 ]
Huang, Gendong [1 ]
Dai, Min [1 ]
Zhang, Bin [1 ]
机构
[1] Nanchang Univ, Affiliated Hosp 1, Artificial Joints Engn & Technol Res Ctr Jiangxi, Dept Orthoped, Nanchang 330006, Jiangxi, Peoples R China
[2] Nanchang Univ, Dept Coll Pharm, Nanchang, Jiangxi, Peoples R China
来源
ORTHOPADE | 2018年 / 47卷 / 03期
关键词
Neurofibroma; Case study; Recurrence; Surgery; Computed tomography; SOFT-TISSUE PERINEURIOMA; BREAST-CANCER; BENIGN-TUMORS; FACIAL-NERVE; NF1; HETEROZYGOSITY; SPECTRUM; PATHOGENESIS; POPULATION; GERMLINE;
D O I
10.1007/s00132-017-3518-z
中图分类号
R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学(修复外科学)];
学科分类号
摘要
Neurofibromatosis type 1 is an autosomal dominant inherited disease, which is characterized by the presence of multiple neurofibromas. We encountered a case in which a sporadic dispersed neurofibroma recurred locally on numerous occasions extending over 16 years. The patient developed multiple masses with a focus of neurofibroma on the right lower limb, which were excised. The patient was initially diagnosed with inflammatory changes via computed tomography and magnetic resonance imaging; however, subsequently, pathological and immunohistochemical examinations revealed an intraneural neurofibroma. The patient underwent a comprehensive and complete local resection several times. After a continuous postoperative follow-up strategy, the patient recovered well. This report describes a case of primary manifestations of multiple and recurrent neurofibromas. We aim to emphasize the possibility of a unique, recurrent, non-healing neurofibroma and review the diagnostic techniques utilized to reach a definitive diagnosis. Early and complete surgical resection is an effective method to treat and prevent this type of neurofibroma.
引用
收藏
页码:254 / 259
页数:6
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