Metabolomic approaches to study the tumor microenvironment

被引：2
|
作者：
Astarita, Giuseppe [1 ]
Dhungana, Suraj [2 ]
Shrestha, Bindesh [2 ]
Laiakis, Evagelia C. [1 ,3 ]
机构：
[1] Georgetown Univ, Dept Biochem & Mol & Cellular Biol, Washington, DC 20007 USA
[2] Waters Corp, Milford, MA USA
[3] Georgetown Univ, Lombardi Comprehens Canc Ctr, Dept Oncol, Washington, DC 20007 USA
来源：
TUMOR IMMUNOLOGY AND IMMUNOTHERAPY - INTEGRATED METHODS, PT B | 2020年 / 636卷
基金：
美国国家卫生研究院;
关键词：
MASS-SPECTROMETRY; CANCER METABOLISM; BRAIN; HETEROGENEITY; HALLMARKS; TISSUE; SERUM;
D O I：
10.1016/bs.mie.2019.07.037
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Tumors are characterized by metabolic dysregulation, reprogramming, and the presence of metabolites, which can act both as energy mediators and signaling messengers. Measuring the concentration and composition of metabolites in the tumor microenvironment can help to better understand the tumor pathology and might improve therapeutic treatments. Metabolomics can provide a description of the physiological and pathological status, as well as help to identify biomarkers of the disease. Additionally, mass spectrometry-based tissue imaging techniques can show the spatial distribution of metabolites. In this chapter we present protocols for the extraction and analysis of metabolites and lipids, with emphasis on liquid chromatography-mass spectrometry and mass spectrometry imaging.
引用
收藏
页码：93 / 108
页数：16
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